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SUMO4 anticorps (Middle Region)

SUMO4 Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN356785
  • Antigène Voir toutes SUMO4 Anticorps
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Épitope
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 48
    • 18
    • 18
    Humain
    Hôte
    • 45
    • 3
    Lapin
    Clonalité
    • 38
    • 10
    Polyclonal
    Conjugué
    • 24
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp SUMO4 est non-conjugé
    Application
    • 32
    • 23
    • 20
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody is specific to SUMO4 (Center).
    Purification
    Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
    Immunogène
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human SUMO4.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SUMO4 Anticorps primaire
  • Indications d'application
    ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry on paraffin sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Antigène
    SUMO4 (Small Ubiquitin Related Modifier 4 (SUMO4))
    Autre désignation
    SUMO4 / SMT3H4 (SUMO4 Produits)
    Synonymes
    anticorps IDDM5, anticorps SMT3H4, anticorps SUMO-4, anticorps dJ281H8.4, anticorps small ubiquitin-like modifier 4, anticorps small ubiquitin-related modifier 4, anticorps SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae), anticorps SUMO4, anticorps sumo4
    Sujet
    SUMO4 is a member of the SUMO gene family. This family of small ubiquitin-related modifiers covalently modify target lysines in proteins and control the target proteins' subcellular localization, stability, or activity. Upon oxidative stress, SUMO4 conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. This protein may also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to SUMO4 substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. In contrast to SUMO1, SUMO2 and SUMO3, SUMO4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90. This may impair processing to mature form and conjugation to substrates. SUMO4 is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. The M55V substitution has been associated with type I diabetes.Synonyms: SUMO-4, Small ubiquitin-like protein 4, Small ubiquitin-related modifier 4
    ID gène
    387082, 9606
    UniProt
    Q6EEV6
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