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GCAP1 anticorps (C-Term)

GUCA1A Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN357117
  • Antigène Voir toutes GCAP1 (GUCA1A) Anticorps
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Épitope
    • 15
    • 9
    • 5
    • 3
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 20
    • 18
    • 17
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 34
    • 1
    Lapin
    Clonalité
    • 34
    • 1
    Polyclonal
    Conjugué
    • 12
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GCAP1 est non-conjugé
    Application
    • 29
    • 17
    • 13
    • 13
    • 10
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects GCAP1 at C-term.
    Purification
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogène
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human GCAP1.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product GUCA1A Anticorps primaire
  • Indications d'application
    ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))
    Autre désignation
    GCAP1 / GUCA1A (GUCA1A Produits)
    Synonymes
    anticorps C6orf131, anticorps COD3, anticorps CORD14, anticorps GCAP, anticorps GCAP1, anticorps GUCA, anticorps GUCA1, anticorps dJ139D8.6, anticorps MGC84170, anticorps GUCA1A, anticorps guca1a, anticorps MGC146317, anticorps GC-A, anticorps Gcap1, anticorps Guca1, anticorps mGCAP1, anticorps gcap1, anticorps guanylate cyclase activator 1A, anticorps guanylate cyclase activator 1A L homeolog, anticorps guanylate cyclase activator 1A (retina), anticorps guanylate cyclase activator 1a (retina), anticorps GUCA1A, anticorps Guca1a, anticorps guca1a.L, anticorps guca1a
    Sujet
    Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90 % similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.Synonyms: C6orf131, GUCA1, Guanylate cyclase activator 1A, Guanylyl cyclase-activating protein 1
    Poids moléculaire
    22774 Da
    ID gène
    2978, 9606
    UniProt
    P43080
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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