SIGLEC8 anticorps (C-Term)

N° du produit ABIN357149

Détail du produit anti-SIGLEC8 anticorps

Antigène: SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGLEC8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects SIGLEC8 at C-term.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human SIGLEC8.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Détails sur SIGLEC8

Antigène: SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))

Autre désignation: CD329 / SIGLEC8 (SIGLEC8 Produits)

Synonymes: anticorps SAF2, anticorps SIGLEC-8, anticorps SIGLEC8L, anticorps SIGLEC8, anticorps sialic acid binding Ig like lectin 8, anticorps sialic acid-binding Ig-like lectin 8, anticorps SIGLEC8, anticorps LOC506364

Sujet: SIGLEC8 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. It preferentially binds to alpha2,3-linked sialic acid. and also binds to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC8 is expressed specifically on eosinophils. The protein contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The SIGLEC8 gene belongs to the immunoglobulin superfamily.Synonyms: CDw329, SAF2, Sialic acid-binding Ig-like lectin 8, Sialoadhesin family member 2, Siglec-8

Poids moléculaire: 54042 Da

ID gène: 27181, 9606

UniProt: Q9NYZ4