BMPR1A
Reactivité: Humain
WB, ELISA, IHC, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Antigène
BMPR1A
(Bone Morphogenetic Protein Receptor 1A (BMPR1A))
anticorps 10q23del, anticorps ACVRLK3, anticorps ALK3, anticorps CD292, anticorps SKR5, anticorps 1110037I22Rik, anticorps AU045487, anticorps BMPR-IA, anticorps Bmpr, anticorps BMPR-1, anticorps BRK-1, anticorps BMPR1A, anticorps acvrlk3, anticorps alk-3, anticorps alk3, anticorps cd292, anticorps skr5, anticorps BR1a, anticorps alk3tr, anticorps bmpr1a, anticorps zgc:136731, anticorps wu:fe05b06, anticorps wu:fe06e10, anticorps zgc:92227, anticorps bone morphogenetic protein receptor type 1A, anticorps bone morphogenetic protein receptor, type 1A, anticorps bone morphogenetic protein receptor type 1A S homeolog, anticorps bone morphogenetic protein receptor, type IAa, anticorps bone morphogenetic protein receptor, type IAb, anticorps BMPR1A, anticorps Bmpr1a, anticorps bmpr1a, anticorps bmpr1a.S, anticorps bmpr1aa, anticorps bmpr1ab
Sujet
The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. Both activins and TGF-beta transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMP receptors are highly expressed in bone, skeletal muscle, heart and liver tissue. BMPRs play a crucial role during development as mutations or deletions to the BMPR genes can cause juvenile polyposis, disrupt normal dorsal/ventral patterning during limb development, and may be a factor in the progession of Cowden-like syndrome. Germline mutations in the BMPR2 gene encoding bone morphogenetic protein (BMP) type II receptor (BMPR-II) have been reported in patients with primary pulmonary hypertension (PPH).Synonyms: ACVRLK3, ALK-3, ALK3, Activin receptor-like kinase 3, Bone morphogenetic protein receptor type-1A, SKR5, Serine/threonine-protein kinase receptor R5