CRY1 anticorps (C-Term)

N° du produit ABIN358613

Détail du produit anti-CRY1 anticorps

Antigène: CRY1 (Cryptochrome 1 (Photolyase-Like) (CRY1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CRY1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to CRY1.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide C-terminal region of human Cry1.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur CRY1

Antigène: CRY1 (Cryptochrome 1 (Photolyase-Like) (CRY1))

Autre désignation: Cryptochrome-1 (CRY1 Produits)

Synonymes: anticorps cry1-A, anticorps CRY1, anticorps cry2, anticorps phll1, anticorps xCRY1, anticorps PHLL1, anticorps AU020726, anticorps AU021000, anticorps Phll1, anticorps ATCRY1, anticorps BLU1, anticorps BLUE LIGHT UNINHIBITED 1, anticorps CRYPTOCHROME 1 APOPROTEIN (BLUE LIGHT PHOTORECEPTOR, anticorps ELONGATED HYPOCOTYL 4, anticorps HY4, anticorps OOP2, anticorps OUT OF PHASE 2, anticorps T3H13.14, anticorps T3H13_14, anticorps cryptochrome 1, anticorps cryptochrome circadian clock 1 L homeolog, anticorps cryptochrome circadian regulator 1, anticorps cryptochrome circadian clock 1, anticorps Cryptochrome-1, anticorps cryptochrome 1, anticorps cryptochrome 1 (photolyase-like), anticorps cry1.L, anticorps CRY1, anticorps cry1, anticorps siu50817b, anticorps Cry1

Sujet: Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central gears driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function, in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.Synonyms: CRY1, PHLL1

ID gène: 1407, 9606

UniProt: Q16526

Pathways: Response to Water Deprivation, Proton Transport