LRP6 anticorps (C-Term)

N° du produit ABIN358636

Détail du produit anti-LRP6 anticorps

Antigène: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to LRP6.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP6.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blot: 1/100 - 1/500. Immunohistochemistry: 1/10 - 1/50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur LRP6

Antigène: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Autre désignation: LRP6 (LRP6 Produits)

Synonymes: anticorps lrp6-A, anticorps Xlrp6, anticorps adcad2, anticorps lrp6, anticorps LRP6, anticorps ADCAD2, anticorps C030016K15Rik, anticorps Cd, anticorps Gw, anticorps LDL receptor related protein 6, anticorps LDL receptor related protein 6 L homeolog, anticorps LDL receptor related protein 6 S homeolog, anticorps low density lipoprotein receptor-related protein 6, anticorps low-density lipoprotein receptor-related protein 6, anticorps LRP6, anticorps lrp6.L, anticorps lrp6.S, anticorps lrp6, anticorps Lrp6, anticorps LOC590395

Sujet: LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.Synonyms: LRP-6, Low-density lipoprotein receptor-related protein 6

ID gène: 4040, 9606

UniProt: O75581

Pathways: Signalisation WNT, Tube Formation