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MLLT10 anticorps (C-Term)

MLLT10 Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN358670
  • Antigène Voir toutes MLLT10 Anticorps
    MLLT10 (Protein AF-10 (MLLT10))
    Épitope
    • 16
    • 8
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 48
    • 19
    • 13
    Humain
    Hôte
    • 46
    • 3
    • 1
    Lapin
    Clonalité
    • 47
    • 3
    Polyclonal
    Conjugué
    • 20
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MLLT10 est non-conjugé
    Application
    • 38
    • 19
    • 14
    • 14
    • 6
    • 6
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody reacts to MLLT10.
    Purification
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogène
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MLLT10.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MLLT10 Anticorps primaire
  • Indications d'application
    ELISA: 1/1000. Western Blot: 1/100 - 1/500. Immunohistochemistry: 1/10 - 1/50.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Antigène
    MLLT10 (Protein AF-10 (MLLT10))
    Autre désignation
    MLLT10 / AF10 (MLLT10 Produits)
    Synonymes
    anticorps AF10, anticorps Af10, anticorps B130021D15Rik, anticorps D630001B22Rik, anticorps mKIAA4140, anticorps MLLT10, histone lysine methyltransferase DOT1L cofactor, anticorps myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10, anticorps MLLT10, anticorps Mllt10
    Sujet
    Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t(10,11)(p12,q23) translocations. In an analysis of two leukemia patients, the in t(10,11)(p12,q23) translocation fuses MLL1, a SET domain containg histone methyltransferase, to the MLLT10 gene. The MLLT10 gene encodes a predicted 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain. The MLLT10 gene is one of the few MLL partner genes to be independently rearranged with a third gene in leukemia, the CALM gene in the t(10,11)(p12,q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 consistently retain the leucine zipper motif of MLLT10. The leucine zipper interacts with GAS41, a protein previously identified as the product of an amplified gene in a glioblastoma. GAS41 interacts with integrase interactor-1 (INI1), a component of the SWI/SNF complex, which acts to remodel chromatin and to modulate transcription. Retention of the leucine zipper in the MLL and CALM fusions suggested that a key feature of these chimeric proteins may be their ability to interfere in normal gene regulation through interaction with the adenosine triphosphate-dependent chromatin remodeling complexes.Synonyms: myeloid/lymphoid or mixed-lineage leukemia translocated to 10
    ID gène
    8028, 9606
    UniProt
    P55197
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