PACSIN1
Reactivité: Humain
WB, IHC (p), ICC, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Antigène
PACSIN1
(Protein Kinase C and Casein Kinase Substrate in Neurons 1 (PACSIN1))
anticorps MGC84055, anticorps sdpii, anticorps pacsin1, anticorps x-PACSIN2, anticorps fe25d06, anticorps wu:fe25d06, anticorps zgc:114042, anticorps PACSIN1, anticorps SDPI, anticorps A830061D09Rik, anticorps H74, anticorps mKIAA1379, anticorps syndapin, anticorps protein kinase C and casein kinase substrate in neurons 1, anticorps protein kinase C and casein kinase substrate in neurons 1 S homeolog, anticorps protein kinase C and casein kinase substrate in neurons 2, anticorps protein kinase C and casein kinase substrate in neurons 1b, anticorps PACSIN1, anticorps pacsin1.S, anticorps pacsin2, anticorps pacsin1b, anticorps Pacsin1
Sujet
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.Synonyms: KIAA1379, Protein kinase C and casein kinase substrate in neurons protein 1