NEFH anticorps

N° du produit ABIN361351

Détail du produit anti-NEFH anticorps

Antigène: NEFH (Neurofilament, Heavy Polypeptide (NEFH))

Reactivité: Boeuf (Vache)

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp NEFH est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: Specific for the ~200k Neurofilament H protein.

Réactivité croisée: Poulet, Mammifères

Purification: Total IgY fraction

Immunogène: Purified bovine NF-H

Information d'application

Indications d'application: Recommended Dilution: WB: 1:50,000 IF: 1:25,000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: total IgY fraction in PBS + 10 mM Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-NEFH (ABIN361351)

Malara, Lutz, Incearap, Bauer, Cursano, Volbracht, Lerner, Pandey, Delling, Ioannidis, Arévalo, von Bernhardi, Schön, Bockmann, Dimou, Boeckers: "SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system." dans: Cellular and molecular life sciences : CMLS, Vol. 79, Issue 7, pp. 371, (2022) (PubMed).

Détails sur NEFH

Antigène: NEFH (Neurofilament, Heavy Polypeptide (NEFH))

Autre désignation: NEFH (NEFH Produits)

Synonymes: anticorps NF-H, anticorps NF200, anticorps Nfh, anticorps mKIAA0845, anticorps NFH, anticorps NEFH, anticorps neurofilament heavy polypeptide, anticorps neurofilament, heavy polypeptide, anticorps neurofilament heavy, anticorps MCYG_06231, anticorps Nefh, anticorps NEFH

Sujet: Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H (1). NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) (2) and Alzheimer's disease (3). Anti-Neurofilament H Left: Western blot of rat cortex lysate showing specific immunolableing of the ~200k NF-H protein. Right: Immunofluorescence of rat cortical neurons and glia showing NF-H staining (red).

Poids moléculaire: '200 kDa

ID gène: 4744

UniProt: P12036