NEFM anticorps (C-Term)

N° du produit ABIN361355

Détail du produit anti-NEFM anticorps

Antigène: NEFM (Neurofilament Triplet M Protein (NEFM))

Épitope: C-Term

Reactivité: Rat

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp NEFM est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: Specific for the ~145k Neurofilament M protein.

Réactivité croisée: Poulet, Boeuf (Vache), Humain, Souris, Rat (Rattus)

Purification: Total IgY fraction

Immunogène: Preparation containing the extreme C-terminus expressed in and purified from E. Coli

Information d'application

Indications d'application: Recommended Dilution: WB: 1:5,000 IF: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: total IgY fraction in PBS + 10 mM Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-NEFM (ABIN361355)

Glass, Kelm-Nelson, Szot, Lake, Connor, Ciucci: "Functional characterization of extrinsic tongue muscles in the Pink1-/- rat model of Parkinson disease." dans: PloS one, Vol. 15, Issue 10, pp. e0240366, (2020) (PubMed).

Détails sur NEFM

Antigène: NEFM (Neurofilament Triplet M Protein (NEFM))

Autre désignation: NEFM (NEFM Produits)

Sujet: Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H (1). NF-M is the neurofilament middle or medium molecular weight polypeptide and runs on SDS-PAGE gels at 145-160 kDa, with some variability across species boundaries. Antibodies to NF-M are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-M antibodies can also be useful to visualize neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (Lou Gehrig's disease) and Alzheimer's disease (2). Anti-Neurofilament M Western blot of rat cortex lysate showing specific immunolableing of the ~ 145k NF-M protein.

Poids moléculaire: '145 kDa

ID gène: 24588

UniProt: P12839

Pathways: Brown Fat Cell Differentiation