Rho-related GTP-binding protein anticorps

N° du produit ABIN361366

Détail du produit anti-Rho-related GTP-binding protein anticorps

Antigène: Rho-related GTP-binding protein (RhO (pan))

Reactivité: Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Rho-related GTP-binding protein est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for the ~ 39k rhodopsin protein.

Réactivité croisée: Amphibien, Mammifères

Purification: Protein G purified culture supernatant

Immunogène: Purified native bovine rhodopsin

Clone: 1D4

Isotype: IgG1

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 IHC: 1:100 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Références pour anticorps anti-Rho-related GTP-binding protein (ABIN361366)

Cho, Song, Shin, Kim: "Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model." dans: BMC ophthalmology, Vol. 16, Issue 1, pp. 193, (2017) (PubMed).

Kim, Park, Lee, Shin, Nickas, Kim, Cho: "Yap is essential for retinal progenitor cell cycle progression and RPE cell fate acquisition in the developing mouse eye." dans: Developmental biology, Vol. 419, Issue 2, pp. 336-347, (2017) (PubMed).

Détails sur Rho-related GTP-binding protein

Antigène: Rho-related GTP-binding protein (RhO (pan))

Autre désignation: RHO (RhO (pan) Produits)

Classe de substances: Chemical

Sujet: Rhodopsin is a photoreceptor protein found in retinal rods. It is a complex formed by the binding of retinaldehyde, the oxidized form of retinol, to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. The disease-causing protein generally aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins which leads to photoreceptor apoptosis (Berson et al., 1991). Other mutations on rhodopsin lead to X-linked congenital stationary night blindness, mainly due to constitutive activation, when the mutations occur around the chromophore binding pocket of rhodopsin (Dryja et al.,1993). Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulative activation, rod outer segment instability and arrestin binding. Anti-Rhodopsin Immunohistochemical staining of mouse retinal section showing specific immunolabeling of the rhodopsin protein in the rod spherules. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA.

Poids moléculaire: '39 kDa

ID gène: 509933

UniProt: P02699