NMDAR2A anticorps (C-Term)

N° du produit ABIN361396

Détail du produit anti-NMDAR2A anticorps

Antigène: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Épitope: C-Term

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NMDAR2A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Specificité: Specific for the ~180k NR2A subunit of the NMDA receptor. Recognizes human, mouse and rat forms of the NR2A subunit of NMDAR. No reactivity towards the NR2B and NR2C subunits. Immunolabeling is blocked by pre-adsorption of antibody with the fusion protein used to generate the antibody.

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Fusion protein from the C-terminal region of the NR2A subunit

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 IHC (frozen sections, unpublished observations): 1:1000 to 1:2000 IP: 3 µl per 200 µg lysate Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized

Stock: -20 °C

Références pour anticorps anti-NMDAR2A (ABIN361396)

Morimura, Yasuda, Yamaguchi, Katayama, Hatayama, Tomioka, Odagawa, Kamiya, Iwayama, Maekawa, Nakamura, Matsuzaki, Tsujii, Yamada, Yoshikawa, Aruga: "Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice." dans: Nature communications, Vol. 8, pp. 15800, (2018) (PubMed).

Détails sur NMDAR2A

Antigène: NMDAR2A (GRIN2A) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2a (GRIN2A))

Autre désignation: GRIN2A (GRIN2A Produits)

Synonymes: anticorps NMDAR2A, anticorps nr2a, anticorps GRIN2A, anticorps EPND, anticorps GluN2A, anticorps NR2A, anticorps glutamate ionotropic receptor NMDA type subunit 2A, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog, anticorps glutamate receptor ionotropic, NMDA 2A, anticorps glutamate receptor, ionotropic, NMDA2A (epsilon 1), anticorps GRIN2A, anticorps grin2a.L, anticorps LOC100438553, anticorps Grin2a

Sujet: The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Anti-NMDA Receptor, NR2A Subunit Western blot of 10 ug of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~180k NR2A subunit of the NMDA receptor.

Poids moléculaire: '180 kDa

ID gène: 24409

UniProt: Q00959

Pathways: Synaptic Membrane, Regulation of long-term Neuronal Synaptic Plasticity