EPH Receptor B2 anticorps (pTyr298)

N° du produit ABIN361466

Détail du produit anti-EPH Receptor B2 anticorps

Antigène: EPH Receptor B2 (EPHB2)

Épitope: pTyr298

Reactivité: Poulet

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor B2 est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for the ~46k EphrinB protein phosphorylated at Tyr298. Immunolabeling of the EphrinB band is blocked by (-phosphatase treatment.

Réactivité croisée: Humain, Rat (Rattus)

Homologie: bovine, canine, chicken, human, mouse, non-human primate, Xenopus, zebra fish

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Synthetic phospho-peptide corresponding to amino acid residues surrounding Tyr298 conjugated to KLH

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Détails sur EPH Receptor B2

Antigène: EPH Receptor B2 (EPHB2)

Autre désignation: EPHB2 (EPHB2 Produits)

Synonymes: anticorps CAPB, anticorps DRT, anticorps EK5, anticorps EPHT3, anticorps ERK, anticorps Hek5, anticorps PCBC, anticorps Tyro5, anticorps ERK2, anticorps ERT1, anticorps MAPK2, anticorps P42MAPK, anticorps PRKM1, anticorps PRKM2, anticorps p38, anticorps p40, anticorps p41, anticorps p41mapk, anticorps RGD1564232, anticorps Cek5, anticorps Drt, anticorps ETECK, anticorps Erk, anticorps Nuk, anticorps Prkm5, anticorps Qek5, anticorps Sek3, anticorps cek5, anticorps ephb2, anticorps xEphB2, anticorps si:ch73-160e9.1, anticorps tpx2, anticorps wu:fb09e10, anticorps wu:fc64a03, anticorps wu:fi18g12, anticorps zgc:112296, anticorps EPH receptor B2, anticorps mitogen-activated protein kinase 1, anticorps Eph receptor B2, anticorps EPH receptor B2 L homeolog, anticorps eph receptor B2a, anticorps eph receptor B2b, anticorps EPHB2, anticorps MAPK1, anticorps Ephb2, anticorps ephb2.L, anticorps ephb2a, anticorps ephb2b

Sujet: EphrinB proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development (Flanagan and Vancerhaeghen, 1998, Dufour et al., 2003, Oike et al., 2002). EphrinB molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cell-to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing EphrinB on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of EphrinB is thought to be a critical component of this reverse signaling event (Palmer et al., 2002). Recent work suggests that phosphorylation of a specific EphrinB residue (Tyr298) plays a key role in EphrinB signaling (Kalo, et al., 2001). Anti-Phospho-Tyr298 EphrinB Western blot of rat testes lysate showing specific immunolabeling of the ~46k EphrinB phosphorylated at Tyr298 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: (-Ptase). The blot is identical to the control except that it was incubated in (-Ptase (1200 units for 30 min) before being exposed to the Anti-Tyr298 EphrinB. The immunolabeling of the EphrinB band is completely eliminated by treatment with (-Ptase.

Poids moléculaire: '46 kDa

ID gène: 396513

UniProt: P28693

Pathways: Signalisation RTK, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins