Glutamate Receptor 1 anticorps (pSer845)

N° du produit ABIN361477

Détail du produit anti-Glutamate Receptor 1 anticorps

Antigène: Glutamate Receptor 1 (GLUR1)

Épitope: pSer845

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Glutamate Receptor 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with human, mouse and non-human primate based on the fact that these species have 100% homology with the amino acid sequence used as antigen. Specific for the ~100k GluR1 protein phosphorylated at Ser845 in Western blots of rat brain extracts. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Immunolabeling is completely eliminated by treatment with λ-Ptase.

Réactivité croisée: Souris, Rat (Rattus)

Homologie: human, non-human primates

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser845 conjugated to KLH

Information d'application

Indications d'application: WB: 1:1000. IHC: 1:1000 (frozen sections).

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Références pour anticorps anti-Glutamate Receptor 1 (ABIN361477)

Hikida, Morita, Kuroiwa, Macpherson, Shuto, Sotogaku, Niwa, Sawa, Nishi: "Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice." dans: Neuroscience research, Vol. 151, pp. 38-45, (2020) (PubMed).

Mao, Wang: "Upregulation of AMPA receptor GluA1 phosphorylation by blocking adenosine A1 receptors in the male rat forebrain." dans: Brain and behavior, Vol. 10, Issue 3, pp. e01543, (2020) (PubMed).

Musante, Li, Kanyo, Lam, Colangelo, Cheng, Brody, Greengard, Le Novère, Nairn: "Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition." dans: eLife, Vol. 6, (2018) (PubMed).

Hollis, Sevelinges, Grosse, Zanoletti, Sandi: "Involvement of CRFR1 in the Basolateral Amygdala in the Immediate Fear Extinction Deficit." dans: eNeuro, Vol. 3, Issue 5, (2017) (PubMed).

Zhang, Fu, Fu, Ip: "S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength." dans: Nature communications, Vol. 6, pp. 8665, (2016) (PubMed).

Ip, Fu, Cheng, Tong, Lok, Liang, Ye, Ip: "Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection." dans: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 40, Issue 8, pp. 1877-87, (2015) (PubMed).

Mao, Xue, Jin, Wang: "Dynamic increases in AMPA receptor phosphorylation in the rat hippocampus in response to amphetamine." dans: Journal of neurochemistry, Vol. 133, Issue 6, pp. 795-805, (2015) (PubMed).

Suzuki, Harada, Shiraishi, Kimura: "In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents." dans: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 471-9, (2015) (PubMed).

Tassin, Benavides, Plattner, Nishi, Bibb: "Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain." dans: The Journal of biological chemistry, Vol. 290, Issue 26, pp. 16319-29, (2015) (PubMed).

Mao, Hastings, Fibuch, Wang: "Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice." dans: European journal of pharmacology, Vol. 738, pp. 237-44, (2014) (PubMed).

Wang, Zhang, Xu, Zhu, Wang, He, Zhang, Guo, Kong, Huang, Li: "Fluoxetine improves behavioral performance by suppressing the production of soluble β-amyloid in APP/PS1 mice." dans: Current Alzheimer research, Vol. 11, Issue 7, pp. 672-80, (2014) (PubMed).

Bernard, Castano, Bayer, Benke: "Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures." dans: Neuropharmacology, Vol. 84, pp. 1-12, (2014) (PubMed).

Xue, Edwards, Mao, Guo, Jin, Fibuch, Wang: "Rapid and sustained GluA1 S845 phosphorylation in synaptic and extrasynaptic locations in the rat forebrain following amphetamine administration." dans: Neurochemistry international, Vol. 64, pp. 48-54, (2013) (PubMed).

Shen, Fu, Cheng, Fu, Ip: "Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 2, pp. 464-72, (2013) (PubMed).

Davis, Olausson, Greengard, Taylor, Nairn: "Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits." dans: The European journal of neuroscience, Vol. 35, Issue 2, pp. 300-8, (2012) (PubMed).

Ferrario, Loweth, Milovanovic, Wang, Wolf: "Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens." dans: Neuroscience letters, Vol. 490, Issue 3, pp. 180-4, (2011) (PubMed).

Kuroiwa, Snyder, Shuto, Fukuda, Yanagawa, Benavides, Nairn, Bibb, Greengard, Nishi: "Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex." dans: Psychopharmacology, (2011) (PubMed).

Torres-Altoro, Mathur, Drerup, Thomas, Lovinger, OCallaghan, Bibb: "Organophosphates dysregulate dopamine signaling, glutamatergic neurotransmission, and induce neuronal injury markers in striatum." dans: Journal of neurochemistry, Vol. 119, Issue 2, pp. 303-13, (2011) (PubMed).

Ferrario, Loweth, Milovanovic, Ford, Galiñanes, Heng, Tseng, Wolf: "Alterations in AMPA receptor subunits and TARPs in the rat nucleus accumbens related to the formation of Ca²?-permeable AMPA receptors during the incubation of cocaine craving." dans: Neuropharmacology, Vol. 61, Issue 7, pp. 1141-51, (2011) (PubMed).

Sears, Liu, Narayanan, Sharf, Yeckel, Laubach, Aghajanian, DiLeone: "Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 24, pp. 8263-73, (2010) (PubMed).

Détails sur Glutamate Receptor 1

Antigène: Glutamate Receptor 1 (GLUR1)

Autre désignation: GRIA1 (GLUR1 Produits)

Synonymes: anticorps GLUH1, anticorps GLUR1, anticorps GLURA, anticorps GluA1, anticorps HBGR1, anticorps gluR-A, anticorps 2900051M01Rik, anticorps Glr-1, anticorps Glr1, anticorps GluR-A, anticorps GluRA, anticorps Glur-1, anticorps Glur1, anticorps HIPA1, anticorps gluR-K1, anticorps GRIA1, anticorps glur1, anticorps Gria1, anticorps glur1b, anticorps gria1.2, anticorps sb:eu293, anticorps ZfGluR1a, anticorps glur1a, anticorps gria1.1, anticorps zfGRIA1[a], anticorps glutamate ionotropic receptor AMPA type subunit 1, anticorps glutamate receptor, ionotropic, AMPA1 (alpha 1), anticorps glutamate receptor, ionotropic, AMPA 1, anticorps glutamate receptor, ionotropic, AMPA 1 L homeolog, anticorps GluR1 protein, anticorps Glutamate receptor 1, anticorps glutamate receptor, ionotropic, AMPA 1b, anticorps glutamate receptor, ionotropic, AMPA 1a, anticorps GRIA1, anticorps Gria1, anticorps gria1, anticorps gria1.L, anticorps glur1, anticorps glr-1, anticorps gria1b, anticorps gria1a

Sujet: Affinity purified rabbit polyclonal antibody. Biological Significance: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. Phosphorylation of Ser845 on GluR1 is thought to be mediated by PKA and phosphorylation of this site increases the conductance of the AMPAR (Roche et al., 1996; Banke et al., 2000). In addition, phosphorylation of this site has been linked to synaptic plasticity as well as arning and memory (Lee at al., 2003; Esteban at al., 2003).

Poids moléculaire: '100 kDa

ID gène: 50592

UniProt: P19490

Pathways: Signalisation PI3K-Akt