YWHAB anticorps (pSer58)

N° du produit ABIN361482

Détail du produit anti-YWHAB anticorps

Antigène: YWHAB (14-3-3 alpha + beta (YWHAB))

Épitope: pSer58

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YWHAB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for the ~29k 14-3-3 protein phosphorylated at Ser58. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.

Réactivité croisée: Humain, Rat (Rattus)

Homologie: bovine, canine, chicken, mouse, non-human primates, sheep, Xenopus, zebra fish

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser58 conjugated to KLH

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 IHC: 1:500 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Détails sur YWHAB

Antigène: YWHAB (14-3-3 alpha + beta (YWHAB))

Autre désignation: YWHAB (YWHAB Produits)

Synonymes: anticorps GW128, anticorps HS1, anticorps KCIP-1, anticorps YWHAA, anticorps 1300003C17Rik, anticorps wu:fb22g04, anticorps wu:fr86a12, anticorps ywhab, anticorps ywhab2, anticorps zgc:64092, anticorps 14-3-3beta, anticorps fb80c08, anticorps fk41f08, anticorps wu:fb80c08, anticorps wu:fd11d01, anticorps wu:fk41f08, anticorps ywhab1, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta S homeolog, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta L homeolog, anticorps tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a, anticorps YWHAB, anticorps Ywhab, anticorps ywhabb, anticorps ywhab.S, anticorps ywhab.L, anticorps ywhaba

Sujet: 14-3-3 proteins are a family of highly conserved proteins that appear to have multiple roles in cell signaling (Bridges and Moorhead, 2005). The proteins are abundantly expressed in the brain and have been detected in the cerebrospinal fluid of patients with different neurological disorders (Berg et al., 2003). 14-3-3 proteins bind protein ligands that are typically phosphorylated on serine or threonine residues and regulate the functions of these binding partners by a number of different mechanisms (Silhan et al., 2004, Dougherty and Morrison, 2004). The14-3-3 proteins affect a diverse array of cellular processes including the cell cycle and transcription, signal transduction and intracellular trafficking. These functions of 14-3-3 proteins are facilitated by, if not dependent on, its dimeric structure. Recent work has demonstrated that the dimeric status of the 14-3-3 protein is regulated by site-specific serine phosphorylation (Woodcock et al., 2003). Anti-Phospho-Ser58 14-3-3 Protein Western blot of rat brainstem lysate showing specific immuno- labeling of the ~29k 14-3-3 protein phosphorylated at Ser58 (Control). The immunolabeling is blocked by the phosphopeptide used as the antigen (Phos-pep) but not by the corresponding dephosphopeptide (not shown).

Poids moléculaire: '29 kDa

ID gène: 56011

UniProt: P35213

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, Maintenance of Protein Location