RPS6KA2
Reactivité: Humain, Souris, Rat, Cheval, Lapin, Chien, Cobaye, Porc, Singe, Poulet
WB
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
Restrictions
For Research Use only
Format
Liquid
Buffer
100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
Stock
-20 °C
Hegde, Capell, Ibrahim, Klett, Patel, Sougiannis, Kelly: "Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice." dans: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 41, Issue 12, pp. 2920-2931, (2017) (PubMed).
Antigène
RPS6KA2
(Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))
The p90 ribosomal S6 kinases (RSK)1–4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin–Lowry syndrome, which is characterized by mental retardation and growth deficits (Hanauer and Young, 2002). Recent work suggests that RSK2 exerts a tonic regulation on G-protein coupled signaling (Sheffler et al., 2006). Anti-Ribosomal S6 Kinase Western blot of rat hippocampal lysate showing specific immunolabeling of the ~90k RSK2 protein.