JAK1 anticorps (pTyr1022)
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- Antigène Voir toutes JAK1 Anticorps
- JAK1 (Janus Kinase 1 (JAK1))
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Épitope
- pTyr1022
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp JAK1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- The antibody detects endogenous level of JAK1 only when phosphorylated at tyrosine 1022.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
- Immunogène
- Peptide sequence around phosphorylation site of pTyr1022 (K-E-Y (p) -Y-T) derived from Human JAK1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
- Isotype
- IgG
- Top Product
- Discover our top product JAK1 Anticorps primaire
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- Indications d'application
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Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway." dans: Journal of cancer research and clinical oncology, Vol. 137, Issue 11, pp. 1629-40, (2011) (PubMed).
: "Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling." dans: Stem cells (Dayton, Ohio), Vol. 28, Issue 9, pp. 1476-86, (2010) (PubMed).
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Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway." dans: Journal of cancer research and clinical oncology, Vol. 137, Issue 11, pp. 1629-40, (2011) (PubMed).
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- Antigène
- JAK1 (Janus Kinase 1 (JAK1))
- Autre désignation
- JAK1 (JAK1 Produits)
- Synonymes
- anticorps JAK1A, anticorps JAK1B, anticorps JTK3, anticorps AA960307, anticorps C130039L05Rik, anticorps wu:fb93e10, anticorps jak1, anticorps Janus kinase 1, anticorps tyrosine-protein kinase JAK1, anticorps JAK1, anticorps Jak1, anticorps jak1, anticorps LOC100286690
- Sujet
- Tyrosine kinase of the non-receptor type, involved in the IFN-a/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
- Poids moléculaire
- 130 kDa
- NCBI Accession
- NP_002218
- UniProt
- P23458
- Pathways
- Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response
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