HDAC5 anticorps (AA 496-500)
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- Antigène Voir toutes HDAC5 Anticorps
- HDAC5 (Histone Deacetylase 5 (HDAC5))
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Épitope
- AA 496-500
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HDAC5 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- The antibody detects endogenous level of total HDAC5 protein.
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.
- Immunogène
- Peptide sequence around AA 496-500 (T-Q-S-S-P) derived from Human HDAC5, 7. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Isotype
- IgG
- Top Product
- Discover our top product HDAC5 Anticorps primaire
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- Indications d'application
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Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS." dans: Blood, Vol. 115, Issue 14, pp. 2971-9, (2010) (PubMed).
: "GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells." dans: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 5, pp. 892-8, (2008) (PubMed).
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Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS." dans: Blood, Vol. 115, Issue 14, pp. 2971-9, (2010) (PubMed).
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- Antigène
- HDAC5 (Histone Deacetylase 5 (HDAC5))
- Autre désignation
- HDAC5 (HDAC5 Produits)
- Synonymes
- anticorps HD5, anticorps NY-CO-9, anticorps AI426555, anticorps Hdac4, anticorps mHDA1, anticorps mKIAA0600, anticorps ATHDA5, anticorps HDA5, anticorps MAF19.7, anticorps MAF19_7, anticorps histone deacetylase 5, anticorps histone deacetylase 5, anticorps HDAC5, anticorps Hdac5, anticorps HDA05, anticorps hdac5
- Sujet
- Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
- Poids moléculaire
- 124 kDa
- NCBI Accession
- NP_001015
- UniProt
- Q9UQL6
- Pathways
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Monocarboxylic Acid Catabolic Process
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