The antibody detects endogenous level of total Integrin b3 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatographyusing epitope-specific immunogen.
Immunogène
Peptide sequence around AA 783-787 (I-T-Y-R-G) derived from Human Integrin B3, ITGB3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with a and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct a subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-a2B or the Itg-Beta3 subunit