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FAK anticorps (AA 574-578, AA 575-579)
PTK2
Reactivité: Humain, Souris, Rat
IHC
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-FAK anticorps
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Antigène
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FAK (PTK2)
(PTK2 Protein tyrosine Kinase 2 (PTK2))
Épitope
Tous les épitopes à travers FAK Anticorps.
AA 574-578, AA 575-579
Reactivité
Toutes les réactivités sur FAK Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur FAK Anticorps
Lapin
Clonalité
Toutes les clonalités sur FAK Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers FAK Anticorps
Cet anticorp FAK est non-conjugé
Application
Tous les applications à travers FAK Anticorps.
Immunohistochemistry (IHC)
Specificité
The antibody detects endogenous level of total FAK protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen .
Immunogène
Peptide sequence around AA 574-578, 575-579 (T-Y-Y-K-A) derived from Human FAK. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Isotype
IgG
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Information d'application
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Indications d'application
Western blotting: 1:500-1:1000 Immunohistochemistry: 1:50-1:100
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C/-20 °C
Stockage commentaire
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Références pour anticorps anti-FAK (ABIN363118)
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Ruan, Liu, Zhang, Yan, Fan, Shen, Wang, Zheng, Wang, Lu : "Luteolin reduces the invasive potential of malignant melanoma cells by targeting ?3 integrin and the epithelial-mesenchymal transition. " dans: Acta pharmacologica Sinica , Vol. 33 , Issue 10 , pp. 1325-31 , (2012 ) (PubMed ).
Détails sur FAK
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Antigène
FAK (PTK2)
(PTK2 Protein tyrosine Kinase 2 (PTK2))
Autre désignation
FAK (PTK2 Produits )
Synonymes
anticorps FADK, anticorps FAK, anticorps FAK1, anticorps FRNK, anticorps PPP1R71, anticorps p125FAK, anticorps pp125FAK, anticorps PTK2, anticorps Fadk, anticorps mKIAA4203, anticorps fak, anticorps fak1a, anticorps ptk2, anticorps ptk2a, anticorps wu:fa18c04, anticorps zgc:66114, anticorps CG10023, anticorps CT28129, anticorps DFAK, anticorps DFak, anticorps DFak56, anticorps Dfak, anticorps Dfak56, anticorps DmFAK, anticorps Dmel\\CG10023, anticorps Fak56, anticorps Fak56D, anticorps fak56, anticorps protein tyrosine kinase 2, anticorps protein tyrosine kinase 2 L homeolog, anticorps PTK2 protein tyrosine kinase 2, anticorps protein tyrosine kinase 2ab, anticorps Focal adhesion kinase, anticorps PTK2, anticorps ptk2.L, anticorps Ptk2, anticorps ptk2ab, anticorps Fak
Sujet
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Poids moléculaire
125 kDa
UniProt
Q05397
Pathways
Response to Growth Hormone Stimulus , CXCR4-mediated Signaling Events , Smooth Muscle Cell Migration , Signaling of Hepatocyte Growth Factor Receptor , VEGF Signaling
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