EPAS1 anticorps (AA 535-631)

N° du produit ABIN363209

Détail du produit anti-EPAS1 anticorps

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Épitope: AA 535-631

Reactivité: Humain, Souris, Rat, Hamster

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EPAS1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Chromatin Immunoprecipitation (ChIP)

Specificité: Reacts with HIF-2 alpha from human, mouse hamster and rat

Réactivité croisée (Details): Does not cross-react with HIF-1 alpha.

Purification: Purified (protein G)

Immunogène: Human HIF-2 alpha amino acids 535-631

Clone: Ep190b

Isotype: IgG1

Information d'application

Indications d'application:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
ELISA1:100-1:2000, FC1:400, IHC1:150-1:300, WB1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, Sodium azide 0.1 %

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C/-80 °C

Stockage commentaire: Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.

Détails sur EPAS1

Antigène: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Autre désignation: Hypoxia-Inducible Factor 2-alpha (EPAS1 Produits)

Synonymes: anticorps EPAS1, anticorps ECYT4, anticorps HIF2A, anticorps HLF, anticorps MOP2, anticorps PASD2, anticorps bHLHe73, anticorps HIF-2alpha, anticorps HRF, anticorps Hif2a, anticorps bhlhe73, anticorps ecyt4, anticorps hif2, anticorps hif2a, anticorps hif2alpha, anticorps hlf, anticorps mop2, anticorps pasd2, anticorps EPAS, anticorps EPAS-1, anticorps endothelial PAS domain protein 1, anticorps endothelial PAS domain protein 1 L homeolog, anticorps EPAS1, anticorps epas1, anticorps Epas1, anticorps epas1.L

Sujet: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

ID gène: 2034

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, L'effet Warburg