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Collagen Type I anticorps

COL1 Reactivité: Humain, Souris, Mammifères, Poisson, Amphibien, Avian WB, IHC (fro), IHC (p), IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN372599
  • Antigène Voir toutes Collagen Type I (COL1) Anticorps
    Collagen Type I (COL1) (Collagen, Type I (COL1))
    Reactivité
    • 99
    • 63
    • 58
    • 21
    • 17
    • 17
    • 16
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Mammifères, Poisson, Amphibien, Avian
    Hôte
    • 65
    • 38
    • 14
    Lapin
    Clonalité
    • 79
    • 38
    Polyclonal
    Conjugué
    • 57
    • 14
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Cet anticorp Collagen Type I est non-conjugé
    Application
    • 70
    • 48
    • 38
    • 33
    • 30
    • 27
    • 27
    • 27
    • 20
    • 19
    • 16
    • 6
    • 5
    • 5
    • 5
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Specificité
    Specific for the ~180 kDa Collagen I Alpha-1 Propeptide in Human lung fibroblast extract.
    Réactivité croisée (Details)
    Species reactivity (expected):most (if not all) Species of Mammals, Birds, Amphibians and Fishes.
    Species reactivity (tested):Human and Mouse.
    Purification
    Affinity Chromatography.
    Immunogène
    Peptide from the Human Collagen I Alpha-1 propeptide sequence.
    Isotype
    IgG
    Top Product
    Discover our top product COL1 Anticorps primaire
  • Indications d'application
    Western Blot: 1/1000. Immunohistochemitry: 1/100. The antibody also works well for Immunohistochemistry on Paraformaldehyde-FixedSections with a simple antigen-retrieval protocol (incubate slides for 20 minutes at 90 °C in10 mM sodium citrate ( pH 6.0)/ 0.1 % Tween-20). Note that in Paraffin Sections of Formaldehyde-Fixed fibrotic mouse lung tissue, itrecognizes collagen I molecules that are still associated with the cells in which they weresynthesized.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Liquid in PBS. Contains no preservative
    Agent conservateur
    Without preservative
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody undiluted (in aliquots) at-20 °C.
  • Marneros: "Effects of chronically increased VEGF-A on the aging heart." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 32, Issue 3, pp. 1550-1565, (2018) (PubMed).

    Granata, Santoro, Masola, Tomei, Sallustio, Pontrelli, Accetturo, Antonucci, Carratù, Lupo, Zaza: "In Vitro Identification of New Transcriptomic and miRNomic Profiles Associated with Pulmonary Fibrosis Induced by High Doses Everolimus: Looking for New Pathogenetic Markers and Therapeutic Targets." dans: International journal of molecular sciences, Vol. 19, Issue 4, (2018) (PubMed).

    Goggins, Kakkad, Mironchik, Jacob, Wildes, Krishnamachary, Bhujwalla: "Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts." dans: Neoplasia (New York, N.Y.), Vol. 20, Issue 2, pp. 131-139, (2018) (PubMed).

  • Antigène
    Collagen Type I (COL1) (Collagen, Type I (COL1))
    Autre désignation
    Collagen Type I (COL1 Produits)
    Synonymes
    anticorps collagen type III alpha 1 chain, anticorps COL3A1
    Sujet
    Collagen is the most abundant protein in mammals with type 1 collagen being the most abundant of the 29 known collagens. Type 1 collagen is integral in the strengthening and structural support of many tissues including skin, tendon, artery walls, fibrocartilage, bone and teeth. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the fist 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procoallagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005).Synonyms: Alpha-1 type I collagen, Alpha-2 type I collagen, COL1A1, COL1A2
    ID gène
    1277
    NCBI Accession
    NP_000079
    UniProt
    P02452
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