GABRG2 anticorps (pSer327)
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- Antigène Voir toutes GABRG2 Anticorps
- GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))
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Épitope
- pSer327
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Chien, Poulet, Non-Human Primate
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GABRG2 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- Specific for ~45k GABAA Receptor Gamma2 subunit phosphorylated at Ser327. Immunolabeling of the GABAA band is completely blocked by Lambda-phosphatase treatment.
- Réactivité croisée (Details)
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Species reactivity (expected):Human, Bovine, Canine, Chicken, Mouse and non-Human Primates.
Species reactivity (tested):Rat. - Purification
- Sequential Chromatography on phospho- and dephospho-peptide affinity columns.
- Immunogène
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser327 of the GABAA Receptor, Gamma2 subunit.
- Isotype
- IgG
- Top Product
- Discover our top product GABRG2 Anticorps primaire
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- Indications d'application
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Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody undiluted (in aliquots) at-20 °C.
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- Antigène
- GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))
- Autre désignation
- GABRG2 (GABRG2 Produits)
- Synonymes
- anticorps cae2, anticorps eca2, anticorps gabrg1, anticorps gefsp3, anticorps si:ch211-145n14.1, anticorps CAE2, anticorps ECA2, anticorps GEFSP3, anticorps GABAA-R, anticorps Gabrg-2, anticorps gamma2, anticorps gamma-aminobutyric acid type A receptor gamma2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, gamma 2, anticorps gamma-aminobutyric acid type A receptor gamma 2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2, anticorps GABRG2, anticorps gabrg2, anticorps Gabrg2
- Sujet
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKC-epsilon regulates the sensitivity of GABAA Alpha1/Beta2/Gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of Gamma2 (Qi et al., 2007)Synonyms: GABA A Receptor subunit gamma-2, GABRG-2, Gamma-aminobutyric acid receptor subunit gamma-2
- ID gène
- 29709
- NCBI Accession
- NP_899156
- UniProt
- P18508
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