OLIG2
Reactivité: Humain
WB, IHC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western blot: 1/3000. Immunohistochemistry: 1/1000. Immunocytochemistry: 1/1000. Immunoprecipitation: 1/500-1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Buffer
100 mM Glycine, 200 mM Tris, pH 8.0 without preservatives.
Agent conservateur
Without preservative
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Stockage commentaire
Store the antibody undiluted (in aliquots) at-20 °C.
Norwood, Franklin, Sharma, DMello: "Histone deacetylase 3 is necessary for proper brain development." dans: The Journal of biological chemistry, Vol. 289, Issue 50, pp. 34569-82, (2014) (PubMed).
Bains, Tourkina, Atkinson, Joseph, Tholanikunnel, Chu, Riemer, Martin, Hoffman: "Loss of caveolin-1 from bronchial epithelial cells and monocytes in human subjects with asthma." dans: Allergy, Vol. 67, Issue 12, pp. 1601-4, (2012) (PubMed).
Davies, Goebel-Goody, Coultrap, Browning: "Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization." dans: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33138-46, (2008) (PubMed).
Guan, Tkatch, Surmeier, Armstrong, Foehring: "Kv2 subunits underlie slowly inactivating potassium current in rat neocortical pyramidal neurons." dans: The Journal of physiology, Vol. 581, Issue Pt 3, pp. 941-60, (2007) (PubMed).
Olig2 is a transcription factor which is required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Expressed in the ventral spinal cord as early as 9.5 dpc and scattered in the mantle zone, likely corresponding to oligodendrocyte progenitors migrating out from their site of origin. From 10.5 through 14.5 dpc, Olig2 is expressed in numerous cells in the ventricular and subventricular zones of the lateral and medial ganglionic eminences, suggesting that expression might not be limited to the oligodendrocytic lineage. Olig2 has further been shown to be critical in the proliferation of malignant glioma in brain tumors (Ligon et al., 2007).Synonyms: BHLHB1, Class B basic helix-loop-helix protein 1, OLIG2, Oligo2, Oligodendrocyte transcription factor 2, PRKCBP2, Protein kinase C-binding protein 2, Protein kinase C-binding protein RACK17, RACK17, bHLHB1