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Parkin anticorps (pSer378)
PARK2
Reactivité: Humain
WB
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-Parkin anticorps
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Antigène
Voir toutes Parkin (PARK2) Anticorps
Parkin (PARK2)
(Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
Épitope
Tous les épitopes à travers Parkin Anticorps.
pSer378
Reactivité
Toutes les réactivités sur Parkin Anticorps
Humain
Hôte
Toutes les hôtes sur Parkin Anticorps
Lapin
Clonalité
Toutes les clonalités sur Parkin Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers Parkin Anticorps
Cet anticorp Parkin est non-conjugé
Application
Tous les applications à travers Parkin Anticorps.
Western Blotting (WB)
Specificité
This antibody recognizes the ~52k Parkin protein phosphorylated at Ser378. Immunolabeling of the parkin band is absent in parkin S378 mutants.
Réactivité croisée (Details)
Species reactivity (tested):Human.
Purification
Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
Immunogène
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser378 of human Parkin.
Isotype
IgG
Top Product
Discover our top product PARK2 Anticorps primaire
Alternatives
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Information d'application
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Indications d'application
Western blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Buffer
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Stockage commentaire
Store the antibody undiluted (in aliquots) at-20 °C.
Détails sur Parkin
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Antigène
Parkin (PARK2)
(Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2))
Autre désignation
PARK2 / Parkin (PARK2 Produits )
Synonymes
anticorps CG10523, anticorps Dmel\\CG10523, anticorps Dpark, anticorps SD01679, anticorps dpk, anticorps AR-JP, anticorps LPRS2, anticorps PDJ, anticorps PRKN, anticorps Park, anticorps Prkn, anticorps si:ch211-123f21.1, anticorps zgc:112390, anticorps pdr-1, anticorps PARK2, anticorps parkin, anticorps parkin RBR E3 ubiquitin protein ligase, anticorps Parkinson disease (autosomal recessive, juvenile) 2, parkin, anticorps park, anticorps PRKN, anticorps Prkn, anticorps prkn, anticorps CpipJ_CPIJ014867, anticorps Park2
Sujet
Parkin is an E3 ligase in the ubiquitin-proteasome system. Hereditary Parkinson's disease is most commonly caused by mutations in the parkin gene and is characterized by the progressive loss of dopaminergic neurons and the presence of Lewy bodies in the substania nigra (Jenner et al.,1992). Recent evidence suggests that phosphorylation of parkin at Ser378 may have an important regulatory role on its E3 ubiquitin ligase activity (Yamamoto et al., 2005).Synonyms: AR-JP, E3 ubiquitin-protein ligase parkin, LPRS2, PDJ, PRKN, Parkinson disease 2, Parkinson juvenile disease protein 2
ID gène
5071
NCBI Accession
NP_004553
UniProt
O60260
Pathways
Autophagy , Ubiquitin Proteasome Pathway
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