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STK10-A anticorps (pSer482, pSer486, pSer490)
STK10-A
Reactivité: Humain, Souris, Poisson zèbre (Danio rerio), Rat, Xenopus laevis
WB
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-STK10-A anticorps
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Antigène
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STK10-A
(Serine/threonine Kinase 10 (STK10-A))
Épitope
Tous les épitopes à travers STK10-A Anticorps.
pSer482, pSer486, pSer490
Reactivité
Toutes les réactivités sur STK10-A Anticorps
Humain, Souris, Poisson zèbre (Danio rerio), Rat, Xenopus laevis
Hôte
Toutes les hôtes sur STK10-A Anticorps
Lapin
Clonalité
Toutes les clonalités sur STK10-A Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers STK10-A Anticorps
Cet anticorp STK10-A est non-conjugé
Application
Tous les applications à travers STK10-A Anticorps.
Western Blotting (WB)
Specificité
This antibody recognizes the ~120k PLKK protein phosphorylated at Ser482,486,490.
Réactivité croisée (Details)
Species reactivity (expected):Human, Mouse, Rat and Zebrafish. Species reactivity (tested):Xenopus.
Purification
Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
Immunogène
Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser482,486,490 of Xenopus polo-like kinase kinase (PLKK).
Isotype
IgG
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Alternatives
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Information d'application
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Indications d'application
Western blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Buffer
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Stockage commentaire
Store the antibody undiluted (in aliquots) at-20 °C.
Détails sur STK10-A
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Antigène
STK10-A
(Serine/threonine Kinase 10 (STK10-A))
Autre désignation
PLKK1 (STK10-A Produits )
Synonymes
anticorps LOK, anticorps PRO2729, anticorps Gek1, anticorps Lok, anticorps mKIAA4026, anticorps zgc:63495, anticorps plkk1, anticorps stk10, anticorps xPlkk1, anticorps serine/threonine kinase 10, anticorps serine/threonine kinase 10 S homeolog, anticorps STK10, anticorps Stk10, anticorps stk10, anticorps stk10.S
Sujet
Considerable evidence indicates that a polo-like kinase (PLK) plays an important role in cell cycle regulation. PLK is also required for bipolar spindle formation, activation of the anaphase-promoting complex/cyclosome, and cytokinesis. Recent work led to the identification of a PLKK that is thought to be responsible for activation of PLK. Recent work (Erikson, et al., 2004) has shown that PLKK is in turn activated by phosphorylation at three sites (Ser482, Ser486 and Ser490). Thus activation of PLK is thought to involve a kinase cascade involving the phosphorylation of Ser482,486,490 in PLKK.Synonyms: Polo-like kinase kinase 1, stk10, xPlkk1
ID gène
373731
NCBI Accession
NP_001079164
UniProt
Q9YHC9
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