SYN1 anticorps (pSer549)

N° du produit ABIN372720

Détail du produit anti-SYN1 anticorps

Antigène: SYN1 (Synapsin I (SYN1))

Épitope: pSer549

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Non-Human Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Dot Blot (DB)

Specificité: This antibody recognizes the ~78k Synapsin I doublet protein phosphorylated at Ser549. Immunolabeling of the synapsin I band is blocked by lambda-phosphatase treatment.

Réactivité croisée (Details): Species reactivity (expected):Human, Bovine, Canine, Mouse and non-Human Primates.
Species reactivity (tested):Rat.

Purification: Sequential Chromatography on phospho- and dephosphopeptide affinity columns.

Immunogène: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser549 of Synapsin I.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/1,000. Immunohistochemistry: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur SYN1

Antigène: SYN1 (Synapsin I (SYN1))

Autre désignation: Synapsin-1 (SYN1 Produits)

Sujet: Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002, Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001, Kao et al., 2002). Ser 549 along with Ser 62 and Ser 67 are the sites of synapsin I that are phosphorylated by MAP kinase (Jovanovic et al., 1996). Phosphorylation and subsequent dephosphorylation of this site is thought to play a key role in synaptic vesicle trafficking.Synonyms: Brain protein 4.1, SYN1, Synapsin I

ID gène: 6853

NCBI Accession: NP_008881

UniProt: P17600