PAG1 anticorps (AA 97-432)
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- Antigène Voir toutes PAG1 Anticorps
- PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))
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Épitope
- AA 97-432
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PAG1 est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody recognizes Csk-binding protein (Cbp / PAG), a 46 kDa ubiquitously expressed transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule.
- Réactivité croisée (Details)
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. - Purification
- Affinity Purified
- Immunogène
- Recombinant intracellular fragment (aa 97-432) of human Cbp (PAG)
- Top Product
- Discover our top product PAG1 Anticorps primaire
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- Indications d'application
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Immunohistochemistry on paraffin sections: 10 μg/mL. Western blot. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS, 15 mM sodium azide, approx., pH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- Antigène
- PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))
- Autre désignation
- PAG1 / Csk-Binding Protein (PAG1 Produits)
- Synonymes
- anticorps Cbp, anticorps F730007C19Rik, anticorps Pag, anticorps CBP, anticorps PAG, anticorps MGC80192, anticorps phosphoprotein associated with glycosphingolipid microdomains 1, anticorps phosphoprotein membrane anchor with glycosphingolipid microdomains 1, anticorps phosphoprotein membrane anchor with glycosphingolipid microdomains 1 L homeolog, anticorps Pag1, anticorps PAG1, anticorps pag1.L, anticorps pag1
- Sujet
- Csk binding protein, also known as PAG (phosphoprotein associated with GEMs), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.Synonyms: CBP, PAG, Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp
- ID gène
- 55824
- NCBI Accession
- NP_060910
- UniProt
- Q9NWQ8
- Pathways
- Signalisation p53, TCR Signaling, EGFR Signaling Pathway, CXCR4-mediated Signaling Events
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