SERPINI2
Reactivité: Humain, Souris, Rat
WB, IF (p), IHC (p)
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Peptide ELISA: Antibody detection limit dilution: 1/64000. Western Blot: 0.3-1 μg/mL. Approx 40 kDa band observed in Human Pancreas lysates (calculated MW of 46.0 kDaaccording to NP_006208.1 and 47.0 kDa and NP_001012303.1). Immunohistochemistry on Paraffin Sections: 3 μg/mL. In paraffin embedded Human Pancreas, shows cytoplasmic staining of acinar cels and ofrare cells in the islets of Langerhans. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0.5 mg/mL
Buffer
Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preserative and 0.5 % BSA as stabilizer.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Antigène
SERPINI2
(serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 (SERPINI2))
anticorps Spi14, anticorps MEPI, anticorps PANCPIN, anticorps PI14, anticorps TSA2004, anticorps serpin family I member 2, anticorps serpin peptidase inhibitor, clade I (pancpin), member 2 L homeolog, anticorps serpin peptidase inhibitor, clade I (pancpin), member 2, anticorps serine (or cysteine) peptidase inhibitor, clade I, member 2, anticorps SERPINI2, anticorps serpini2.L, anticorps Serpini2
Sujet
MEP1 is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. It may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.Synonyms: MEPI, Myoepithelium-derived serine protease inhibitor, PI14, Pancpin, Protease inhibitor 14, TSA2004