POMC anticorps (C-Term)
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- Antigène Voir toutes POMC Anticorps
- POMC (Proopiomelanocortin (POMC))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp POMC est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Séquence
- C-NAIIKNAYKK GE
- Specificité
- In Western blot, this antibody appears to react with the full length precursor protein only.
- Réactivité croisée (Details)
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Species reactivity (expected):Rat.
Species reactivity (tested):Human and Mouse. - Purification
- Immunoaffinity Chromatography
- Immunogène
- Synthetic Peptide corresponding to C-Terminal of Human POMC (according to NP_000930.1, NP_001030333.1) Genename: POMC
- Top Product
- Discover our top product POMC Anticorps primaire
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- Indications d'application
- Peptide ELISA: Detection Limit Dilution: 1/32,000. Western Blot: Use at 0.01-0.03 μg/mL. Detects a band of approx. 26 kDa band in lysates of Mouse pituitary cell line NIH3T3. Immunohistochemistry: Use at 2-4 μg/mL. In Paraffin Embedded Human Adrenal Gland shows strong cytoplasm staining in selectcells in the medulla.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month (in aliquots) at -20 °C for longer.
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- Antigène
- POMC (Proopiomelanocortin (POMC))
- Autre désignation
- POMC (POMC Produits)
- Synonymes
- anticorps MSH, anticorps ACTH, anticorps pomc, anticorps SI:bZ36D5.1, anticorps SI:bZ36D5.4, anticorps si:bz36d5.2, anticorps BE, anticorps Beta-LPH, anticorps Clip, anticorps Gamma-LPH, anticorps Npp, anticorps Pomc-1, anticorps Pomc1, anticorps alpha-MSH, anticorps alphaMSH, anticorps beta-MSH, anticorps gamma-MSH, anticorps CLIP, anticorps LPH, anticorps NPP, anticorps POC, anticorps Pomc2, anticorps proopiomelanocortin a, anticorps pro-opiomelanocortin-alpha, anticorps proopiomelanocortin, anticorps pomca, anticorps Pomc, anticorps POMC
- Sujet
- POMC is a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used, adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. Mutations in POMC gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.Synonyms: Corticotropin-Lipotropin, Pro-opiomelanocortin
- Poids moléculaire
- 29.4kDa (Human NP_000930.1) and 26.7kDa (Mouse NP_032921.1).
- ID gène
- 5443, 9606
- UniProt
- P01189
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour
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