SULF2 anticorps (Internal Region)

N° du produit ABIN375090

Cet anticorps anti-SULF2 Polyclonal Chèvre (ABIN375090) détecte spécifiquement SULF2 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SULF2 anticorps (Internal Region) (ABIN375090)

Antigène: SULF2 (Sulfatase 2 (SULF2))

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp SULF2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SULF2 anticorps

Épitope: Internal Region

Specificité: This antibody is expected to recognize both reported isoforms (NP_061325.1 and NP_940998.1).

Purification: Affinity Chromatography

Immunogène: Peptide with sequence C-DGRVYHVGLGDAAQPR, from the internal region of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/8000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide and 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SULF2

Antigène: SULF2 (Sulfatase 2 (SULF2))

Autre désignation: SULF2

Sujet: Sulf-2 exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Mammalian Sulfs are endoproteolytically processed and secreted into the extracellular space of transfected cells, where they exhibit both arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity against intact heparin. Though the molecular weight of full length human Sulf2 is 100455 Da (870 amino acids), the endogenous Sulf2 is found by western blot to be present at molecular weights of 24.4, 33.7 and 51-60 kDa. Higher molecular weight species may be found depending on tissue and/or cell type. Analysis of human tumor tissue and tumor cell lines suggests that HSulf-1 is misregulated in cancers. HSulf-1 is found in a variety of normal tissues but is down-regulated in tumor cell lines originating from ovarian, breast, pancreatic, renal, and hepatocellular carcinoma. Tumors formed by cells expressing Sulf demonstrate enhanced extracellular matrix deposition. The 6-O-sulfation of heparan sulfate of myeloma tumor cells may be a critical factor in determiningand regulating the in vivo growth of this cancer.Synonyms: Extracellular sulfatase Sulf-2, KIAA1247

ID gène: 55959, 9606

UniProt: Q8IWU5