HAP1 anticorps (Internal Region)
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- Antigène Voir toutes HAP1 Anticorps
- HAP1 (Huntingtin Associated Protein 1 (HAP1))
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Épitope
- Internal Region
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Reactivité
- Humain
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Hôte
- Chèvre
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HAP1 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificité
- This antibody reacts to HAP1. This antibody is expected to recognize all reported isoforms.
- Purification
- Affinity chromatography
- Immunogène
- Peptide with sequence C-RYDFRYSEDREQ, from the internal region of the protein sequence
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- Indications d'application
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ELISA: 1/32000. Western blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- HAP1 (Huntingtin Associated Protein 1 (HAP1))
- Autre désignation
- HAP1 (HAP1 Produits)
- Synonymes
- anticorps HAP2, anticorps HIP5, anticorps HLP, anticorps hHLP1, anticorps HAP1-A, anticorps HAP1-B, anticorps HAP-1, anticorps huntingtin associated protein 1, anticorps huntingtin-associated protein 1, anticorps HAP1, anticorps Hap1
- Sujet
- Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. It is a progressive disorder that generally begins in middle age with abnormalities of movement, cognition, personality and mood. Huntingtin-associated protein-1 is highly expressed in brain and shown to mediate the neuropathology of HD. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified but one is a nonsense-mediated decay (NMD) candidate.Synonyms: HAP-1, HAP2, HLP1, Huntingtin-associated protein 1, Neuroan 1
- ID gène
- 9001
- NCBI Accession
- NP_001073339
- UniProt
- P54257
- Pathways
- Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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