LAMP1 anticorps (FITC)

N° du produit ABIN375461

Détail du produit anti-LAMP1 anticorps (FITC)

Antigène: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LAMP1 est conjugé à/à la FITC

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC)

Specificité: Human/Rhesus/African Green Monkey/Pigtail Macaque/Sooty Mangabey CD107a, Mr 100-120 kDa

Attributs du produit: Mouse Anti-Human CD107a-FITC

Purification: Purified

Immunogène: Human adherent peripheral blood cells

Clone: H4A3

Isotype: IgG1

Information d'application

Indications d'application: Working Dilution:
10 µL/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Restrictions: For Research Use only

Stockage

Conseil sur la manipulation: Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Détails sur LAMP1

Antigène: LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))

Autre désignation: CD107a (LAMP1 Produits)

Synonymes: anticorps CD107a, anticorps LAMPA, anticorps LGP120, anticorps AI196048, anticorps Lamp-1, anticorps LEP100, anticorps LAMP-1, anticorps LGP-A, anticorps Lgpa, anticorps Lysosome-associated membrane protein 1, anticorps cd107a, anticorps lamp-1, anticorps lamp1, anticorps lampa, anticorps lgp120, anticorps rexp76, anticorps lysosomal associated membrane protein 1, anticorps lysosomal-associated membrane protein 1, anticorps lysosomal-associated membrane protein 1 L homeolog, anticorps LAMP1, anticorps Lamp1, anticorps lamp1.L

Sujet: CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.

Pathways: Autophagy