LAMP2 anticorps (FITC)

N° du produit ABIN375463

Détail du produit anti-LAMP2 anticorps (FITC)

Antigène: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LAMP2 est conjugé à/à la FITC

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Specificité: Human/Rhesus/African Green Monkey CD107b, Mr 100-120 kDa

Attributs du produit: Mouse Anti-Human CD107b-FITC

Purification: Purified

Immunogène: Human adherent peripheral blood cells

Clone: H4B4

Isotype: IgG1

Information d'application

Indications d'application: Working Dilution:
10 µL/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Restrictions: For Research Use only

Stockage

Conseil sur la manipulation: Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Détails sur LAMP2

Antigène: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Autre désignation: CD107b (LAMP2 Produits)

Synonymes: anticorps CD107b, anticorps LAMP-2, anticorps LAMPB, anticorps LGP110, anticorps Lamp-2, anticorps Lamp-2a, anticorps Lamp-2b, anticorps Lamp-2c, anticorps Mac3, anticorps cd107b, anticorps lamp-2, anticorps lampb, anticorps LAMP2, anticorps lamp2, anticorps DKFZp459J126, anticorps LGP-B, anticorps sb:cb587, anticorps wu:fb14a06, anticorps zgc:103532, anticorps lysosomal associated membrane protein 2, anticorps lysosomal-associated membrane protein 2, anticorps lysosomal-associated membrane protein 2 S homeolog, anticorps lysosomal membrane glycoprotein 2, anticorps LAMP2, anticorps Lamp2, anticorps lamp2.S, anticorps lamp2

Sujet: CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium.

Pathways: Autophagy