TIMP4 anticorps (AA 35-224)

N° du produit ABIN375604

Détail du produit anti-TIMP4 anticorps

Antigène: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Épitope: AA 35-224

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TIMP4 est non-conjugé

Application: Western Blotting (WB)

Specificité: Human/Mouse/Rat TIMP-4

Attributs du produit: Mouse Anti-Human TIMP-4-UNLB

Purification: Purified

Immunogène: Recombinant human TIMP-4 (a.a. 35-224)

Clone: SB30c

Isotype: IgG2a

Information d'application

Indications d'application:

• Applications: WB - Quality tested , ICC , ELISA
• Working Dilutions: Immunoblotting Purified (UNLB) antibody ≤ 2 g/mL HRP conjugate 1:1,000 - 1:2,000

Volume d'échantillon: 0,2 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.1 mg purified immunoglobulin in 0.2 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Détails sur TIMP4

Antigène: TIMP4 (TIMP Metallopeptidase Inhibitor 4 (TIMP4))

Autre désignation: TIMP-4 (TIMP4 Produits)

Synonymes: anticorps TIMP4, anticorps TIMP-4, anticorps timp4, anticorps TIMP metallopeptidase inhibitor 4, anticorps TIMP metallopeptidase inhibitor 4, tandem duplicate 3, anticorps tissue inhibitor of metalloproteinase 4, anticorps TIMP4, anticorps timp4.3, anticorps Timp4

Sujet: Tissue inhibitors of matrix metalloproteinases (TIMPs) constitute a family of secreted multifunctional proteins which are classified based on structural similarity to each other as well as their ability to inhibit matrix metalloproteinases (MMPs). TIMPs therefore play a critical role in ECM homeostasis but have also been shown to have erythroid-potentiating and cell growth-promoting activities. TIMP-4 (approx. 23 kDa), unlike TIMP-1, TIMP-2 and TIMP-3, shows restricted localization to cardiac, neural, breast and muscle tissue. Cardiospecific TIMP-4 seems to play a significant role in regulating the normal cell phenotype since reduced levels elicit cellular transformation. It has been shown to be an inhibitor of MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9 with a preference for MMP-2 and MMP-7.