PRDM2 anticorps (AA 1-347)

N° du produit ABIN387783

Détail du produit anti-PRDM2 anticorps

Antigène: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Épitope: AA 1-347

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRDM2 est non-conjugé

Application: Western Blotting (WB), Chromatin Immunoprecipitation (ChIP)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1. This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).

Clone: 33AT1045

Isotype: IgG1

Information d'application

Indications d'application: CHIP: 1:100. CHIP: 1:100. CHIP: 1:100. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PRDM2 (ABIN387783)

Lakshmikuttyamma, Takahashi, Pastural, Torlakovic, Amin, Garcia-Manero, Voralia, Czader, DeCoteau, Geyer: "RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression." dans: Journal of hematology & oncology, Vol. 2, pp. 28, (2009) (PubMed).

Carling, Kim, Yang, Gu, Zhang, Huang: "A histone methyltransferase is required for maximal response to female sex hormones." dans: Molecular and cellular biology, Vol. 24, Issue 16, pp. 7032-42, (2004) (PubMed).

Détails sur PRDM2

Antigène: PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))

Autre désignation: PRDM2 (RIZ1) (PRDM2 Produits)

Sujet: This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 188915

ID gène: 7799

NCBI Accession: NP_001007258, NP_001129082, NP_036363, NP_056950

UniProt: Q13029