Kdm6b anticorps (C-Term)

N° du produit ABIN387863

Détail du produit anti-Kdm6b anticorps

Antigène: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Épitope: AA 1606-1641, C-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Kdm6b est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: H

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1606-1641 amino acids from the C-terminal region of mouse JMJD3.

Clone: RB10081-RB10082

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-Kdm6b (ABIN387863)

Pham, Yu, Walline, Muthukrishnan, Blum, Kaplan: "Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 2, pp. 902-11, (2013) (PubMed).

Das, Jung, Choi, Yoon, Kim, Chai: "Gene networking and inflammatory pathway analysis in a JMJD3 knockdown human monocytic cell line." dans: Cell biochemistry and function, Vol. 30, Issue 3, pp. 224-32, (2012) (PubMed).

Solá, Xavier, Santos, Aranha, Morgado, Jepsen, Rodrigues: "p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation." dans: PLoS ONE, Vol. 6, Issue 3, pp. e18421, (2011) (PubMed).

McLaughlin-Drubin, Crum, Münger: "Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 5, pp. 2130-5, (2011) (PubMed).

Das, Jung, Chai: "The role of NF-kappaB and H3K27me3 demethylase, Jmjd3, on the anthrax lethal toxin tolerance of RAW 264.7 cells." dans: PLoS ONE, Vol. 5, Issue 3, pp. e9913, (2010) (PubMed).

Détails sur Kdm6b

Antigène: Kdm6b (Lysine (K)-Specific Demethylase 6B (Kdm6b))

Autre désignation: JMJD3 (Kdm6b Produits)

Synonymes: anticorps jmjd3, anticorps kdm6b, anticorps si:ch211-237l4.7, anticorps 1700064E03Rik, anticorps BC038313, anticorps Jmjd3, anticorps mKIAA0346, anticorps JMJD3, anticorps lysine (K)-specific demethylase 6B, anticorps lysine demethylase 6B, anticorps lysine (K)-specific demethylase 6B, b, anticorps KDM1 lysine (K)-specific demethylase 6B, anticorps kdm6b, anticorps KDM6B, anticorps kdm6bb, anticorps Kdm6b

Sujet: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Poids moléculaire: 176355

ID gène: 216850

NCBI Accession: NP_001017426

UniProt: Q5NCY0

Pathways: L'effet Warburg