DNMT3B anticorps (AA 389-417)

N° du produit ABIN387884

Détail du produit anti-DNMT3B anticorps

Antigène: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Épitope: AA 389-417

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNMT3B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This Dnmt3b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-417 amino acids from human Dnmt3b.

Clone: RB01906

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. WB: 1:2000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-DNMT3B (ABIN387884)

Li, Ebert, Li et al.: "T cell receptor (TCR) and transforming growth factor ? (TGF-?) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible ..." dans: The Journal of biological chemistry, Vol. 288, Issue 26, pp. 19127-39, (2013) (PubMed).

Chen, Wang, Hu, Chang, Liao, Dai, Juo: "OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 5, pp. 1718-28, (2011) (PubMed).

Sohn, Park, Lee, Yang, Jang, Park, Kim, Lee, Sohn, Kim, Yoo, Choi, Bae, Yeom: "Functional switching of TGF-beta1 signaling in liver cancer via epigenetic modulation of a single CpG site in TTP promoter." dans: Gastroenterology, Vol. 138, Issue 5, pp. 1898-908, (2010) (PubMed).

Lu, Markowetz, Unwin, Leek, Airoldi, MacArthur, Lachmann, Rozov, Maayan, Boyer, Troyanskaya, Whetton, Lemischka: "Systems-level dynamic analyses of fate change in murine embryonic stem cells." dans: Nature, Vol. 462, Issue 7271, pp. 358-62, (2009) (PubMed).

Yamagata, Asada, Tamura, Lee, Maekawa, Taniguchi, Taketani, Matsuoka, Tamura, Sugino: "DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen." dans: Human reproduction (Oxford, England), Vol. 24, Issue 5, pp. 1126-32, (2009) (PubMed).

Park, Sohn, Yu, Suh, Chung, Lee, Surzycki, Lee: "Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein." dans: Gastroenterology, Vol. 132, Issue 4, pp. 1476-94, (2007) (PubMed).

Fabbri, Garzon, Cimmino, Liu, Zanesi, Callegari, Liu, Alder, Costinean, Fernandez-Cymering, Volinia, Guler, Morrison, Chan, Marcucci, Calin, Huebner, Croce: "MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 40, pp. 15805-10, (2007) (PubMed).

Koturbash, Boyko, Rodriguez-Juarez, McDonald, Tryndyak, Kovalchuk, Pogribny, Kovalchuk: "Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo." dans: Carcinogenesis, Vol. 28, Issue 8, pp. 1831-8, (2007) (PubMed).

Tryndyak, Muskhelishvili, Kovalchuk, Rodriguez-Juarez, Montgomery, Churchwell, Ross, Beland, Pogribny: "Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis." dans: Carcinogenesis, Vol. 27, Issue 8, pp. 1713-20, (2006) (PubMed).

Koturbash, Rugo, Hendricks, Loree, Thibault, Kutanzi, Pogribny, Yanch, Engelward, Kovalchuk: "Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo." dans: Oncogene, Vol. 25, Issue 31, pp. 4267-75, (2006) (PubMed).

Brueckner, Garcia Boy, Siedlecki, Musch, Kliem, Zielenkiewicz, Suhai, Wiessler, Lyko: "Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases." dans: Cancer research, Vol. 65, Issue 14, pp. 6305-11, (2005) (PubMed).

Pogribny, Koturbash, Tryndyak, Hudson, Stevenson, Sedelnikova, Bonner, Kovalchuk: "Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus." dans: Molecular cancer research : MCR, Vol. 3, Issue 10, pp. 553-61, (2005) (PubMed).

Détails sur DNMT3B

Antigène: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Autre désignation: Dnmt3b (DNMT3B Produits)

Synonymes: anticorps DNMT3B, anticorps LOC100218113, anticorps ICF, anticorps ICF1, anticorps M.HsaIIIB, anticorps MmuIIIB, anticorps cb91, anticorps dnmt3bl, anticorps dnmt7, anticorps sb:cb91, anticorps wu:fb16h07, anticorps DNA methyltransferase 3 beta, anticorps DNA methyltransferase 3B, anticorps DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a, anticorps DNMT3B, anticorps Dnmt3b, anticorps dnmt3b, anticorps dnmt3ba

Sujet: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. Dnmt3b is a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF)syndrome.

Poids moléculaire: 95751

ID gène: 1789

NCBI Accession: NP_001193984, NP_001193985, NP_008823, NP_787044, NP_787045, NP_787046

UniProt: Q9UBC3