HDAC9 anticorps (N-Term)

N° du produit ABIN387960

Détail du produit anti-HDAC9 anticorps

Antigène: HDAC9 (Histone Deacetylase 9 (HDAC9))

Épitope: AA 2-32, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC9 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: C, M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This HDAC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human HDAC9.

Clone: RB2582

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:1,000. IP: 1:100. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-HDAC9 (ABIN387960)

Salian-Mehta, Xu, McKinsey, Tobet, Wierman: "Novel Interaction of Class IIb Histone Deacetylase 6 (HDAC6) with Class IIa HDAC9 Controls Gonadotropin Releasing Hormone (GnRH) Neuronal Cell Survival and Movement." dans: The Journal of biological chemistry, Vol. 290, Issue 22, pp. 14045-56, (2015) (PubMed).

Sugo, Oshiro, Takemura, Kobayashi, Kohno, Uesaka, Song, Yamamoto: "Nucleocytoplasmic translocation of HDAC9 regulates gene expression and dendritic growth in developing cortical neurons." dans: The European journal of neuroscience, Vol. 31, Issue 9, pp. 1521-32, (2010) (PubMed).

Deng, Ewton, Mercer, Friedman: "Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation." dans: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4894-905, (2005) (PubMed).

Détails sur HDAC9

Antigène: HDAC9 (Histone Deacetylase 9 (HDAC9))

Autre désignation: HDAC9 (HDAC9 Produits)

Synonymes: anticorps HD7, anticorps HD7b, anticorps HD9, anticorps HDAC, anticorps HDAC7, anticorps HDAC7B, anticorps HDAC9B, anticorps HDAC9FL, anticorps HDRP, anticorps MITR, anticorps AV022454, anticorps D030072B18Rik, anticorps HD7B, anticorps Hdac7b, anticorps Mitr, anticorps mKIAA0744, anticorps hdac9, anticorps zgc:73392, anticorps TWIST, anticorps HDAC9, anticorps DKFZp459E171, anticorps HDA09, anticorps HISTONE DEACETYLASE, anticorps histone deacetylase 9, anticorps RGD1310748, anticorps RGD1563092, anticorps hdac9-A, anticorps histone deacetylase 9, anticorps histone deacetylase 9b, anticorps histone deacetylase 9 S homeolog, anticorps HDAC9, anticorps Hdac9, anticorps hdac9b, anticorps HDA9, anticorps hdac9.S

Sujet: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.

Poids moléculaire: 111297

ID gène: 9734

NCBI Accession: NP_001191073, NP_001191074, NP_001191075, NP_001191076, NP_001191077, NP_055522, NP_478056, NP_848510, NP_848512

UniProt: Q9UKV0

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development