SUV39H1 anticorps (N-Term)

N° du produit ABIN387991

Détail du produit anti-SUV39H1 anticorps

Antigène: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUV39H1 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: Purified recombinant GST fusion protein encoding N-terminal of human SUV39H1.

Clone: RB2153

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-SUV39H1 (ABIN387991)

Chen, Yeh, Yang, Chang, Lee, Hung: "High expressions of histone methylation- and phosphorylation-related proteins are associated with prognosis of oral squamous cell carcinoma in male population of Taiwan." dans: Medical oncology (Northwood, London, England), Vol. 30, Issue 2, pp. 513, (2013) (PubMed).

Benlhabib, Mendelson: "Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia." dans: Molecular and cellular biology, Vol. 31, Issue 10, pp. 1949-58, (2011) (PubMed).

Détails sur SUV39H1

Antigène: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Autre désignation: SUV39H1 (SUV39H1 Produits)

Synonymes: anticorps H3-K9-HMTase 1, anticorps KMT1A, anticorps MG44, anticorps SUV39H, anticorps AI852103, anticorps AL022883, anticorps DXHXS7466e, anticorps mIS6, anticorps RGD1565028, anticorps kmt1a, anticorps suv39h, anticorps fe02c04, anticorps suv39h1, anticorps wu:fe02c04, anticorps zgc:101027, anticorps fe47h06, anticorps wu:fb18a10, anticorps wu:fe47h06, anticorps zgc:136593, anticorps suppressor of variegation 3-9 homolog 1, anticorps suppressor of variegation 3-9 homolog 1 (Drosophila), anticorps suppressor of variegation 3-9 homolog 1 L homeolog, anticorps suppressor of variegation 3-9 homolog 1a, anticorps suppressor of variegation 3-9 homolog 1b, anticorps SUV39H1, anticorps Suv39h1, anticorps suv39h1.L, anticorps suv39h1a, anticorps suv39h1b

Sujet: Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.

Poids moléculaire: 47907

ID gène: 6839

NCBI Accession: NP_001269095, NP_003164

UniProt: O43463