LSD1 anticorps (N-Term)
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- Antigène Voir toutes LSD1 (KDM1A) Anticorps
- LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
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Épitope
- AA 108-142, N-Term
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp LSD1 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogène
- This LSD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-142 amino acids from the N-terminal region of human LSD1.
- Clone
- RB7579-RB7580
- Isotype
- Ig Fraction
- Top Product
- Discover our top product KDM1A Anticorps primaire
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- Indications d'application
- IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Date de péremption
- 6 months
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- Antigène
- LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
- Autre désignation
- LSD1 (KDM1A Produits)
- Sujet
- LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.
- Poids moléculaire
- 92903
- ID gène
- 23028
- NCBI Accession
- NP_001009999, NP_055828
- UniProt
- O60341
- Pathways
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, L'effet Warburg
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