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LSD1 anticorps (C-Term)

KDM1A Reactivité: Humain WB, IF, IHC (p) Hôte: Lapin Polyclonal RB7583 unconjugated
N° du produit ABIN388023
  • Antigène Voir toutes LSD1 (KDM1A) Anticorps
    LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
    Épitope
    • 15
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 819-852, C-Term
    Reactivité
    • 77
    • 37
    • 30
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 59
    • 16
    • 1
    Lapin
    Clonalité
    • 58
    • 19
    Polyclonal
    Conjugué
    • 57
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LSD1 est non-conjugé
    Application
    • 69
    • 36
    • 28
    • 20
    • 16
    • 13
    • 13
    • 10
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    M
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This LSD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 819-852 amino acids from the C-terminal region of human LSD1.
    Clone
    RB7583
    Isotype
    Ig Fraction
    Top Product
    Discover our top product KDM1A Anticorps primaire
  • Indications d'application
    IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Huang, Li, Song, Li, Li, Zhang, Han, Zhang, Miao, Du, Wang: "Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/?-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected]." dans: PLoS ONE, Vol. 8, Issue 7, pp. e70077, (2013) (PubMed).

    Nishikawa, Toyota, Suzuki, Honma, Fujikane, Ohmura, Nishidate, Ohe-Toyota, Maruyama, Sonoda, Sasaki, Urano, Imai, Hirata, Tokino: "Gene amplification and overexpression of PRDM14 in breast cancers." dans: Cancer research, Vol. 67, Issue 20, pp. 9649-57, (2007) (PubMed).

  • Antigène
    LSD1 (KDM1A) (Lysine (K)-Specific Demethylase 1A (KDM1A))
    Autre désignation
    LSD1 (KDM1A Produits)
    Sujet
    LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes.
    Poids moléculaire
    92903
    ID gène
    23028
    NCBI Accession
    NP_001009999, NP_055828
    UniProt
    O60341
    Pathways
    Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Negative Regulation of intrinsic apoptotic Signaling, L'effet Warburg
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