SENP6 anticorps (C-Term)

N° du produit ABIN388052

Il existe 3+ publications pour ce produit. L’anticorps anti-SENP6 Polyclonal Lapin est utilisé pour la détection de SENP6 dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour SENP6 anticorps (C-Term) (ABIN388052)

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SENP6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB0664

Détail du produit anti-SENP6 anticorps

Épitope: AA 1081-1112, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This SENP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1081-1112 amino acids from the C-terminal region of human SENP6.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-SENP6 (ABIN388052)

Lee, Lee, Park, Kang, Yoo, Ka, Oh, Jeon, Chung: "SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage." dans: The EMBO journal, Vol. 31, Issue 23, pp. 4441-52, (2012) (PubMed).

Jones, Fusi, Higham, Abdel-Hafiz, Horwitz, Lam, Brosens: "Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 44, pp. 16272-7, (2006) (PubMed).

Choi, Chung, Rho, Lee, Lee, Choi, Seol, Baek, Bang, Chung: "Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1." dans: The Journal of biological chemistry, Vol. 281, Issue 41, pp. 30669-77, (2006) (PubMed).

Détails sur SENP6

Antigène: SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))

Autre désignation: SENP6

Sujet: SENP6 (SUSP1) is a protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. This protein does not seem to be involved in the processing of full-length SUMO proteins to their mature conjugatable forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.

Poids moléculaire: 126146

ID gène: 26054

NCBI Accession: NP_001093879, NP_056386

UniProt: Q9GZR1