BOK
Reactivité: Humain
Hôte: Lapin
Polyclonal
FITC
Indications d'application
WB: 1:1000. IHC-P: 1:50~100
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Kurata, Yanagisawa, Ohira, Kitagawa, Nakagawara, Kamijo: "Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells." dans: Oncogene, Vol. 27, Issue 6, pp. 741-54, (2008) (PubMed).
Gao, Fu, Dürrenberger, De Geyter, Zhang: "Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3." dans: Cellular and molecular life sciences : CMLS, Vol. 62, Issue 9, pp. 1015-24, (2005) (PubMed).
Yakovlev, Di Giovanni, Wang, Liu, Stoica, Faden: "BOK and NOXA are essential mediators of p53-dependent apoptosis." dans: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28367-74, (2004) (PubMed).
Bok belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains all four BCL-2 like domains (BH1, 2, 3 and 4) and is a pro-apoptotic BCL-2 protein identified in the ovary.