ATG5 anticorps (C-Term)

N° du produit ABIN388519

Détail du produit anti-ATG5 anticorps

Antigène: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Épitope: AA 209-238, C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG5 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ATG5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209-238 amino acids from the C-terminal region of human ATG5.

Clone: RB7547

Isotype: IgG

Information d'application

Indications d'application: IF: 1:25. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze-thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Date de péremption: 6 months

Références pour anticorps anti-ATG5 (ABIN388519)

Zhang, Michel, Lenz, Friedel, Köster, dHedouville, Tönges, Urlaub, Bähr, Lingor, Koch: "Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration." dans: Scientific reports, Vol. 6, pp. 37050, (2018) (PubMed).

Radogna, Cerella, Gaigneaux, Christov, Dicato, Diederich: "Cell type-dependent ROS and mitophagy response leads to apoptosis or necroptosis in neuroblastoma." dans: Oncogene, Vol. 35, Issue 29, pp. 3839-53, (2017) (PubMed).

Kessel, Evans: "Promotion of Proapoptotic Signals by Lysosomal Photodamage: Mechanistic Aspects and Influence of Autophagy." dans: Photochemistry and photobiology, Vol. 92, Issue 4, pp. 620-3, (2017) (PubMed).

Zhang, Gao, Zhang, Song, Cheng, Zhou: "The germline-enriched Ppp1r36 promotes autophagy." dans: Scientific reports, Vol. 6, pp. 24609, (2017) (PubMed).

Mathai, Meijer, Simonsen: "Studying Autophagy in Zebrafish." dans: Cells, Vol. 6, Issue 3, (2017) (PubMed).

Du, Ren, Yao, Duan, Zhao, Du, Xiao, Duan, Shi: "Sphingosine kinase 1 protects renal tubular epithelial cells from renal fibrosis via induction of autophagy." dans: The international journal of biochemistry & cell biology, Vol. 90, pp. 17-28, (2017) (PubMed).

Paquet, Nicoll, Love, Mouton-Liger, Holmes, Hugon, Boche: "Downregulated apoptosis and autophagy after anti-Aβ immunotherapy in Alzheimer's disease." dans: Brain pathology (Zurich, Switzerland), (2017) (PubMed).

Wang, Li, Wang, Ma, Chuai, Cao, Yang: "High glucose environment inhibits cranial neural crest survival by activating excessive autophagy in the chick embryo." dans: Scientific reports, Vol. 5, pp. 18321, (2016) (PubMed).

Varga, Fodor, Vellai: "Autophagy in zebrafish." dans: Methods (San Diego, Calif.), Vol. 75, pp. 172-80, (2015) (PubMed).

Ribas, Schnepf, Challagundla, Koch, Bähr, Lingor: "Early and sustained activation of autophagy in degenerating axons after spinal cord injury." dans: Brain pathology (Zurich, Switzerland), Vol. 25, Issue 2, pp. 157-70, (2015) (PubMed).

Hsin, Ou, Wu, Jan, Hsiao, Lin, Ko: "GMI, an Immunomodulatory Protein from Ganoderma microsporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells." dans: Molecular pharmaceutics, Vol. 12, Issue 5, pp. 1534-43, (2015) (PubMed).

Xin, Xiao, Ma, He, Yao, Liu et al.: "Coxsackievirus B3 induces crosstalk between autophagy and apoptosis to benefit its release after replicating in autophagosomes through a mechanism involving caspase cleavage of autophagy-related ..." dans: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, Vol. 26, pp. 95-102, (2014) (PubMed).

Degtyarev, Reichelt, Lin: "Novel quantitative autophagy analysis by organelle flow cytometry after cell sonication." dans: PLoS ONE, Vol. 9, Issue 1, pp. e87707, (2014) (PubMed).

Yao, Jia, Shelby, Ganios, Feathers, Thompson, Zacks: "Circadian and noncircadian modulation of autophagy in photoreceptors and retinal pigment epithelium." dans: Investigative ophthalmology & visual science, Vol. 55, Issue 5, pp. 3237-46, (2014) (PubMed).

Al-Zeer, Al-Younes, Lauster, Abu Lubad, Meyer: "Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins." dans: Autophagy, Vol. 9, Issue 1, pp. 50-62, (2013) (PubMed).

Zhang, Morgan, Chen, Choksi, Liu: "Induction of autophagy is essential for monocyte-macrophage differentiation." dans: Blood, Vol. 119, Issue 12, pp. 2895-905, (2012) (PubMed).

Chiu, Chen, Ho, Wang: "Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells." dans: PLoS ONE, Vol. 7, Issue 2, pp. e31579, (2012) (PubMed).

Hu, Zhang, Zhang: "Expression pattern and functions of autophagy-related gene atg5 in zebrafish organogenesis." dans: Autophagy, Vol. 7, Issue 12, pp. 1514-27, (2012) (PubMed).

Norberg, Karlsson, Korenovska, Szydlowski, Silberberg, Uhlén, Orrenius, Zhivotovsky: "Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis." dans: The EMBO journal, Vol. 29, Issue 22, pp. 3869-78, (2010) (PubMed).

Dou, Chattopadhyay, Pan, Guerriero, Jiang, Ballou, Yue, Lin, Zong: "The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy." dans: The Journal of cell biology, Vol. 191, Issue 4, pp. 827-43, (2010) (PubMed).

Détails sur ATG5

Antigène: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Autre désignation: ATG5 (ATG5 Produits)

Synonymes: anticorps APG5, anticorps APG5-LIKE, anticorps APG5L, anticorps ASP, anticorps hAPG5, anticorps ATG5, anticorps CG1643, anticorps DmAtg5, anticorps Dmel\\CG1643, anticorps atg5, anticorps 2010107M05Rik, anticorps 3110067M24Rik, anticorps AW319544, anticorps Apg5l, anticorps Atg5l, anticorps C88337, anticorps Paddy, anticorps apg5l, anticorps zgc:100934, anticorps ATATG5, anticorps AUTOPHAGY 5, anticorps MKP11.20, anticorps MKP11_20, anticorps autophagy related 5, anticorps Autophagy-related 5, anticorps ATG5 autophagy related 5 homolog (S. cerevisiae), anticorps autophagy related 5 L homeolog, anticorps similar to S. cerevisiae ATG5 (YPL149W) which nucleates preautophagosome formation as a conjugate with Atg12, anticorps autophagy protein Apg5 family, anticorps ATG5, anticorps Atg5, anticorps atg5, anticorps atg5.L, anticorps APG5

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG5, required for autophagy, conjugates to ATG12 and associates with an isolation membrane to form a cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. APG5 may also play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.

Poids moléculaire: 32447

ID gène: 9474

NCBI Accession: NP_004840

UniProt: Q9H1Y0

Pathways: Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagy