USP2 anticorps (N-Term)

N° du produit ABIN388877

Détail du produit anti-USP2 anticorps

Antigène: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Épitope: AA 71-101, N-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This USP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-101 amino acids from the N-terminal region of human USP2.

Clone: RB4202

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-USP2 (ABIN388877)

Kitamura, Ishino, Shimamoto, Okabe, Miyamoto, Takahashi, Miyoshi: "Ubiquitin-Specific Protease 2 Modulates the Lipopolysaccharide-Elicited Expression of Proinflammatory Cytokines in Macrophage-like HL-60 Cells." dans: Mediators of inflammation, Vol. 2017, pp. 6909415, (2018) (PubMed).

Kitamura, Kimura, Shimamoto, Okabe, Ito, Miyamoto, Naoe, Kikuguchi, Meek, Toda, Okamoto, Kanehira, Hase, Watarai, Ishizuka, El-Osta, Ohara, Miyoshi: "Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 12, pp. 4940-53, (2013) (PubMed).

Stevenson, Sparks, Allende-Vega, Xirodimas, Lane, Saville: "The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2." dans: The EMBO journal, Vol. 26, Issue 4, pp. 976-86, (2007) (PubMed).

Priolo, Tang, Brahamandan, Benassi, Sicinska, Ogino, Farsetti, Porrello, Finn, Zimmermann, Febbo, Loda: "The isopeptidase USP2a protects human prostate cancer from apoptosis." dans: Cancer research, Vol. 66, Issue 17, pp. 8625-32, (2006) (PubMed).

Détails sur USP2

Antigène: USP2 (Ubiquitin Specific Peptidase 2 (USP2))

Autre désignation: USP2 (USP2 Produits)

Synonymes: anticorps UBP41, anticorps USP9, anticorps B930035K21Rik, anticorps Ubp41, anticorps UBP-t, anticorps UBP46, anticorps ubp52, anticorps ubp66, anticorps zgc:92134, anticorps ubiquitin specific peptidase 2, anticorps ubiquitin specific peptidase 2a, anticorps USP2, anticorps Usp2, anticorps usp2a

Sujet: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Poids moléculaire: 68072

ID gène: 9099

NCBI Accession: NP_001230688, NP_004196, NP_741994

UniProt: O75604