USP22 anticorps (N-Term)

N° du produit ABIN388913

Détail du produit anti-USP22 anticorps

Antigène: USP22 (Ubiquitin Specific Peptidase 22 (USP22))

Épitope: AA 1-30, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP22 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This USP22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human USP22.

Clone: RB4357

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-USP22 (ABIN388913)

Kim, Hong, Park, Shin, Yoo, Jeon, Chung: "Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells." dans: Journal of cellular physiology, Vol. 232, Issue 12, pp. 3664-3676, (2017) (PubMed).

Hong, Lee, Chung: "Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination." dans: Journal of cellular physiology, Vol. 230, Issue 7, pp. 1651-60, (2015) (PubMed).

Détails sur USP22

Antigène: USP22 (Ubiquitin Specific Peptidase 22 (USP22))

Autre désignation: USP22 (USP22 Produits)

Synonymes: anticorps USP3L, anticorps AI427806, anticorps zgc:136342, anticorps usp22, anticorps usp22 b, anticorps usp22-B, anticorps usp22-a, anticorps usp3l, anticorps ubiquitin specific peptidase 22, anticorps ubiquitin specific peptidase 22 S homeolog, anticorps USP22, anticorps Usp22, anticorps usp22, anticorps usp22.S

Sujet: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Poids moléculaire: 59961

ID gène: 23326

NCBI Accession: NP_056091

UniProt: Q9UPT9