BAP1 anticorps (AA 36-66)

N° du produit ABIN388948

Détail du produit anti-BAP1 anticorps

Antigène: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Épitope: AA 36-66

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Homologie: B, Zf

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This BAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-66 amino acids of human BAP1.

Clone: RB4559-4560

Isotype: IgG

Information d'application

Indications d'application: IF: 1:25. WB: 1:2000. WB: 1:1000. IHC-P: 1:100. IHC-P: 1:100. FC: 1:25. IHC: 1:250

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.

Date de péremption: 6 months

Références pour anticorps anti-BAP1 (ABIN388948)

Abdel-Rahman, Pilarski, Cebulla, Massengill, Christopher, Boru, Hovland, Davidorf: "Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers." dans: Journal of medical genetics, Vol. 48, Issue 12, pp. 856-9, (2011) (PubMed).

Détails sur BAP1

Antigène: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Autre désignation: BAP1 (BAP1 Produits)

Synonymes: anticorps HUCEP-13, anticorps UCHL2, anticorps BAIAP3, anticorps 2300006C11Rik, anticorps AA989761, anticorps AW553466, anticorps mKIAA0272, anticorps uch-x4, anticorps hucep-13, anticorps hucep-6, anticorps uchl2, anticorps si:dkey-42i9.9, anticorps BRCA1 associated protein 1, anticorps Brca1 associated protein 1, anticorps BRCA1 associated protein 1 L homeolog, anticorps BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), anticorps BAP1, anticorps Bap1, anticorps bap1.L, anticorps bap1

Sujet: 'BRCA1-associated protein-1,' or BAP1 interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin. In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals.. BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns.1 BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth. Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with A 4.8-kb transcript expressed exclusively in testis. Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene has been mapped to 3p21.3, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas.1 Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines. It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway.1

Poids moléculaire: 80362

NCBI Accession: NP_004647

UniProt: Q92560