FDPS anticorps (AA 389-419)

N° du produit ABIN389054

Détail du produit anti-FDPS anticorps

Antigène: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Épitope: AA 389-419

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FDPS est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-419 amino acids from the center region of human FDPS.

Clone: RB04786

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-FDPS (ABIN389054)

Sousa, Auriola, Mönkkönen, Määttä: "Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells." dans: BMC cancer, Vol. 15, pp. 4, (2015) (PubMed).

Todenhöfer, Hennenlotter, Kühs, Gerber, Gakis, Vogel, Aufderklamm, Merseburger, Knapp, Stenzl, Schwentner: "Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?" dans: World journal of urology, Vol. 31, Issue 2, pp. 345-50, (2013) (PubMed).

Zhang, Dai, Wang: "5-Aza-2'-deoxycytidine induced growth inhibition of leukemia cells through modulating endogenous cholesterol biosynthesis." dans: Molecular & cellular proteomics : MCP, Vol. 11, Issue 7, pp. M111.016915, (2012) (PubMed).

Ishimoto, Tachibana, Hanano, Yamasaki, Nakamura, Kawai, Urano, Tanaka, Hamakubo, Sakai, Kodama, Doi: "Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells." dans: The Biochemical journal, Vol. 429, Issue 2, pp. 347-57, (2010) (PubMed).

Räikkönen, Mönkkönen, Auriola, Mönkkönen: "Mevalonate pathway intermediates downregulate zoledronic acid-induced isopentenyl pyrophosphate and ATP analog formation in human breast cancer cells." dans: Biochemical pharmacology, Vol. 79, Issue 5, pp. 777-83, (2010) (PubMed).

Li, Herold, Kimmel, Müller, Rincon-Orozco, Kunzmann, Herrmann: "Reduced expression of the mevalonate pathway enzyme farnesyl pyrophosphate synthase unveils recognition of tumor cells by Vgamma9Vdelta2 T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 12, pp. 8118-24, (2009) (PubMed).

Détails sur FDPS

Antigène: FDPS (Farnesyl Diphosphate Synthase (FDPS))

Autre désignation: FDPS (FDPS Produits)

Synonymes: anticorps CG12389, anticorps DmFPPS, anticorps DmFPPSase, anticorps DmFPS, anticorps Dmel\\CG12389, anticorps FPS, anticorps fpps, anticorps fps, anticorps l(2)k06103, anticorps v(2)k03514, anticorps NCU01175.1, anticorps 16.m00760, anticorps DDBDRAFT_0206220, anticorps DDBDRAFT_0215017, anticorps DDB_0206220, anticorps DDB_0215017, anticorps FPPS, anticorps Ac2-125, anticorps (2E, anticorps 6030492I17Rik, anticorps AI256750, anticorps Fdpsl1, anticorps mKIAA1293, anticorps Farnesyl pyrophosphate synthase, anticorps farnesyl diphosphate synthase, anticorps farnesyl diphosphate synthase L homeolog, anticorps farnesyl pyrophosphate synthase, anticorps farnesyl pyrophosphate synthetase, anticorps farnesyl-pyrophosphate synthetase, anticorps FDP synthase, anticorps Farnesyl pyrophosphate synthetase, anticorps farnesyl diphosphate synthetase, anticorps farnesyl pyrophosphate synthase 1, anticorps Fpps, anticorps fdps, anticorps fdps.L, anticorps MGG_08649, anticorps TP03_0857, anticorps Tb09.160.4300, anticorps fpp, anticorps BBOV_I000120, anticorps fps, anticorps fpps, anticorps FDPS, anticorps Fdps, anticorps fps1

Sujet: The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.

Poids moléculaire: 48275

ID gène: 2224

NCBI Accession: NP_001129293, NP_001129294, NP_001229753, NP_001229754, NP_001995

UniProt: P14324

Pathways: Regulation of Muscle Cell Differentiation