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Androgen Receptor anticorps (AA 365-392)

AR Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal RB2579 unconjugated
N° du produit ABIN389077
  • Antigène Voir toutes Androgen Receptor (AR) Anticorps
    Androgen Receptor (AR)
    Épitope
    • 22
    • 21
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    • 19
    • 17
    • 17
    • 15
    • 13
    • 13
    • 12
    • 11
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    • 8
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    • 3
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    • 2
    • 2
    • 2
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    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 365-392
    Reactivité
    • 311
    • 94
    • 86
    • 29
    • 17
    • 17
    • 15
    • 12
    • 8
    • 4
    • 4
    • 3
    • 1
    Humain, Souris
    Hôte
    • 257
    • 56
    • 1
    • 1
    • 1
    Lapin
    Clonalité
    • 248
    • 66
    Polyclonal
    Conjugué
    • 120
    • 26
    • 14
    • 14
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
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    • 7
    • 7
    • 7
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp Androgen Receptor est non-conjugé
    Application
    • 184
    • 92
    • 65
    • 57
    • 53
    • 38
    • 28
    • 21
    • 19
    • 19
    • 13
    • 10
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Pr, Pig
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This Androgen Receptor (ANDR) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from human Androgen Receptor (ANDR).
    Clone
    RB2579
    Isotype
    Ig Fraction
    Top Product
    Discover our top product AR Anticorps primaire
  • Indications d'application
    WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    Androgen Receptor (AR)
    Autre désignation
    Androgen Receptor (ANDR) (AR Produits)
    Synonymes
    anticorps AIS, anticorps DHTR, anticorps HUMARA, anticorps HYSP1, anticorps KD, anticorps NR3C4, anticorps SBMA, anticorps SMAX1, anticorps TFM, anticorps AW320017, anticorps Tfm, anticorps Andr, anticorps AR, anticorps androgen receptor, anticorps AR, anticorps Ar, anticorps ar
    Sujet
    Androgen receptor (ANDR) has 3 major functional domains: the N-terminal domain, DNA-binding domain, and an androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The gene for this protein contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of the protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations are also associated with complete androgen insensitivity (CAIS). PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor, sumoylation of ANDR represses androgen receptor dependent transcription.
    Poids moléculaire
    99188
    ID gène
    367
    NCBI Accession
    NP_000035, NP_001011645
    UniProt
    P10275
    Pathways
    Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
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